Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

• Published in: Nature communications Vol. 9; no. 1; pp. 365 - 8
• Main Authors: Ezzyat, Youssef, Wanda, Paul A., Levy, Deborah F., Kadel, Allison, Aka, Ada, Pedisich, Isaac, Sperling, Michael R., Sharan, Ashwini D., Lega, Bradley C., Burks, Alexis, Gross, Robert E., Inman, Cory S., Jobst, Barbara C., Gorenstein, Mark A., Davis, Kathryn A., Worrell, Gregory A., Kucewicz, Michal T., Stein, Joel M., Gorniak, Richard, Das, Sandhitsu R., Rizzuto, Daniel S., Kahana, Michael J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1595/2167; 631/378/2649; 631/477/2811; 9/26; Binomial distribution; Brain; Coding; Computer memory; Electrical stimuli; Electrodes; Humanities and Social Sciences; Lobes; multidisciplinary; Probability; Science; Science (multidisciplinary); Stimulation; Temporal lobe
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-017-02753-0

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often...