Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis - Santana-Codina, Naiara; Roeth, Anjali A.; Zhang, Yi; Yang, Annan; Mashadova, Oksana; Asara, John M.; Wang, Xiaoxu; Bronson, Roderick T.; Lyssiotis, Costas A.; Ying, Haoqiang; Kimmelman, Alec C. (Nature communications, 2018)
Keywords: 13; 13/1; 13/106; 13/109; 13/2; 13/31; 13/51; 13/89; 13/95; 631/45/320; 631/67/1504; 631/67/1504/1713; 631/67/2327; 631/67/395; 82/58; 96/63; Adenocarcinoma; Animals; Biosynthesis; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Dependence; Female; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Humans; K-Ras protein; MAP kinase; MAP Kinase Signaling System - drug effects; MEK inhibitors; Metabolism; Mice; Mice, Nude; multidisciplinary; Myc protein; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pentose; Pentose phosphate pathway; Pentose Phosphate Pathway - drug effects; Protein Kinase Inhibitors - administration & dosage; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Pyrimidines - biosynthesis; Science; Science (multidisciplinary); Signal transduction; Transcription