Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

• Published in: Signal transduction and targeted therapy Vol. 6; no. 1; pp. 362 - 25
• Main Authors: Li, Kai, Shi, Houhui, Zhang, Benxia, Ou, Xuejin, Ma, Qizhi, Chen, Yue, Shu, Pei, Li, Dan, Wang, Yongsheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2021; Nature Publishing Group
• Subjects: 631/67/327; 631/67/580; Antitumor agents; Cancer; Cancer Research; Cancer therapies; Cell Biology; Chemotherapy; Clinical trials; Humans; Immune Tolerance - immunology; Immunosuppressive Agents - therapeutic use; Immunotherapy; Internal Medicine; Medicine; Medicine & Public Health; Myeloid cells; Myeloid-Derived Suppressor Cells - immunology; Myeloid-Derived Suppressor Cells - transplantation; Neoplasms - immunology; Neoplasms - therapy; Oncology; Pathology; Radiation therapy; Review; Review Article; Suppressor cells; Therapeutic applications; Tumor Escape - immunology; Tumor Microenvironment - immunology

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological...