Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

• Published in: Nature communications Vol. 13; no. 1; pp. 2921 - 15
• Main Authors: Wang, Chunyan, Hesketh, Emma L., Shamorkina, Tatiana M., Li, Wentao, Franken, Peter J., Drabek, Dubravka, van Haperen, Rien, Townend, Sarah, van Kuppeveld, Frank J. M., Grosveld, Frank, Ranson, Neil A., Snijder, Joost, de Groot, Raoul J., Hurdiss, Daniel L., Bosch, Berend-Jan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 101/1; 101/28; 101/58; 13/109; 38/23; 42; 42/70; 631/250/2152/2153/1291; 631/326/596/2558; 82/80; 82/83; Accessibility; Antibodies; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Antigens; Binding sites; Common cold; Coronavirus OC43, Human - metabolism; Coronaviruses; COVID-19; Epitopes; Evolution & development; Glycoprotein S; Glycoproteins; Herd immunity; Human populations; Humanities and Social Sciences; Humans; Immunity; multidisciplinary; Neutralizing; Protective structures; Respiratory diseases; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Trimers; Viral diseases

Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus on viral glycoprotein S, the target for neutralizing antibodies, and provide an in-depth analysis of i...