Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel - Xu, Lizhen; Han, Yalan; Chen, Xiaoying; Aierken, Aerziguli; Wen, Han; Zheng, Wenjun; Wang, Hongkun; Lu, Xiancui; Zhao, Zhenye; Ma, Cheng; Liang, Ping; Yang, Wei; et al. (Nature communications, 2020)
Keywords: 631/57/2272/2273; 631/92/269/1153; Amino acids; Binding; Binding Sites - genetics; Biophysics; Energy; Fluorescence; Functional testing; HEK293 Cells; Humanities and Social Sciences; Humans; Hydroxyl groups; Ion Channel Gating - drug effects; Ion channels; Laboratories; Ligands; Medicine; Menthol; Menthol - chemistry; Menthol - pharmacology; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular modelling; multidisciplinary; Mutagenesis; Mutants; Mutation; Patch-Clamp Techniques; Point Mutation; Protein Binding; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Science; Science (multidisciplinary); Selectivity; Structure-Activity Relationship; Transient receptor potential proteins; Transmembrane domains; TRPM Cation Channels - agonists; TRPM Cation Channels - chemistry; TRPM Cation Channels - genetics