A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

• Published in: Nature communications Vol. 10; no. 1; pp. 366 - 14
• Main Authors: Song, Yuanbin, Rongvaux, Anthony, Taylor, Ashley, Jiang, Tingting, Tebaldi, Toma, Balasubramanian, Kunthavai, Bagale, Arun, Terzi, Yunus Kasim, Gbyli, Rana, Wang, Xiaman, Fu, Xiaoying, Gao, Yimeng, Zhao, Jun, Podoltsev, Nikolai, Xu, Mina, Neparidze, Natalia, Wong, Ellice, Torres, Richard, Bruscia, Emanuela M., Kluger, Yuval, Manz, Markus G., Flavell, Richard A., Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.01.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/100; 13/31; 45; 45/23; 631/67/71; 64/110; 64/60; 692/699/1541/1990/1673; Animals; Antigens, CD - genetics; Antigens, CD - immunology; Biomarkers - metabolism; Bone marrow; Catalysis; Chemical properties; Cytokines - genetics; Cytokines - immunology; Disease Models, Animal; DNA repair; Efficiency; Fuel cells; Gene Expression; Gene Knock-In Techniques; Genomics; Graft Survival; Hematology; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - immunology; Hematopoietic Stem Cells - pathology; Hospitals; Humanities and Social Sciences; Humans; Immunology; Laboratories; Medical research; Medicine; Mice; Mice, Transgenic; multidisciplinary; Myelodysplastic Syndromes - immunology; Myelodysplastic Syndromes - pathology; Oxides; Patients; Science; Science (multidisciplinary); Stem Cell Niche - immunology; Stem cells; Transplantation, Heterologous; Xenografts

Comprehensive preclinical studies of Myelodysplastic Syndromes (MDS) have been elusive due to limited ability of MDS stem cells to engraft current immunodeficient murine hosts. Here we report a MDS patient-derived xenotransplantation model in cytokine-humanized immunodeficient “MISTRG” mice that pro...