The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation - Capper, Michael J.; Wright, Gareth S. A.; Barbieri, Letizia; Luchinat, Enrico; Mercatelli, Eleonora; McAlary, Luke; Yerbury, Justin J.; O’Neill, Paul M.; Antonyuk, Svetlana V.; Banci, Lucia; Hasnain, S. Samar (Nature communications, 2018)
Keywords: 101/6; 631/154; 631/535/1266; 631/57/2272/2273; 82/16; 82/58; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - drug therapy; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - pathology; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Asthma; Asthma - drug therapy; Asthma - pathology; Azoles - pharmacology; Azoles - therapeutic use; Clinical trials; Crystallography, X-Ray; Cysteine; Cysteine - chemistry; Dimerization; Disulfides; Disulfides - chemistry; Edaravone - pharmacology; Enzymatic activity; Folding; HEK293 Cells; Humanities and Social Sciences; Humans; Isoindoles; Ligands; Maturation; Molecular Chaperones - metabolism; multidisciplinary; Mutation; NMR; Nuclear magnetic resonance; Nuclear Magnetic Resonance, Biomolecular; Oligomers; Organoselenium Compounds - pharmacology; Organoselenium Compounds - therapeutic use; Pathogenicity; Pathogens; Pharmacology; Protein Binding; Protein Folding - drug effects; Protein Multimerization - drug effects; Protein Stability - drug effects; Proteins; Science; Science (multidisciplinary); Superoxide dismutase; Superoxide Dismutase-1 - chemistry; Superoxide Dismutase-1 - genetics; Superoxide Dismutase-1 - metabolism; Therapeutic applications; Toxicity; Zinc