Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

• Published in: Nature communications Vol. 10; no. 1; pp. 3199 - 12
• Main Authors: Liu, Wen-Long, Zou, Mei-Zhen, Liu, Tao, Zeng, Jin-Yue, Li, Xue, Yu, Wu-Yang, Li, Chu-Xin, Ye, Jing-Jie, Song, Wen, Feng, Jun, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.07.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/31; 13/51; 14/1; 14/19; 14/28; 14/35; 59/5; 631/67; 639/925; 64/60; 82/80; Animals; Antigen Presentation - immunology; Antigen-presenting cells; Antigens; Antigens, Neoplasm - immunology; Cancer; Cancer vaccines; Cancer Vaccines - immunology; Cell Fusion; Cell Line, Tumor; Cell Membrane - immunology; Dendritic cells; Dendritic Cells - immunology; Female; Humanities and Social Sciences; Immunology; Immunotherapy; Lymphocyte Activation; Lymphocytes; Lymphocytes T; Mammary Neoplasms, Experimental - immunology; Mammary Neoplasms, Experimental - prevention & control; Mice; Mice, Inbred BALB C; Mimicry; multidisciplinary; Nanoparticles; Nanoparticles - therapeutic use; Science; Science (multidisciplinary); T-Lymphocytes - immunology; Transcriptome; Transplantation, Heterologous; Tumor cells; Tumors; Vaccines

Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines....