Cell fusing agent virus and dengue virus mutually interact in Aedes aegypti cell lines
The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (DENV), West Nile virus, and yellow fever virus. These viruses are transmitted to vert...
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Published in | Scientific reports Vol. 7; no. 1; pp. 6935 - 8 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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31.07.2017
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Abstract | The genus
Flavivirus
contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (DENV), West Nile virus, and yellow fever virus. These viruses are transmitted to vertebrates by mosquitoes and other arthropod species. Mosquitoes are also infected by insect-specific flaviviruses (ISFs) that do not appear to be infective to vertebrates. Cell fusing agent virus (CFAV) was the first described ISF, which was discovered in an
Aedes aegypti
cell culture. We found that while CFAV infection could be significantly reduced by application of RNAi against the
NS5
gene, removal of the treatment led to quick restoration of CFAV replication. Interestingly, we found that CFAV infection significantly enhanced replication of DENV, and vice versa, DENV infection significantly enhanced replication of CFAV in mosquito cells. We have shown that CFAV infection leads to increase in the expression of ribonuclease kappa (RNASEK), which is known to promote infection of viruses that rely on endocytosis and pH-dependent entry. Knockdown of RNASEK by dsRNA resulted in reduced DENV replication. Thus, increased expression of RNASEK induced by CFAV is likely to contribute to enhanced DENV replication in CFAV-infected cells. |
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AbstractList | The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (DENV), West Nile virus, and yellow fever virus. These viruses are transmitted to vertebrates by mosquitoes and other arthropod species. Mosquitoes are also infected by insect-specific flaviviruses (ISFs) that do not appear to be infective to vertebrates. Cell fusing agent virus (CFAV) was the first described ISF, which was discovered in an Aedes aegypti cell culture. We found that while CFAV infection could be significantly reduced by application of RNAi against the NS5 gene, removal of the treatment led to quick restoration of CFAV replication. Interestingly, we found that CFAV infection significantly enhanced replication of DENV, and vice versa, DENV infection significantly enhanced replication of CFAV in mosquito cells. We have shown that CFAV infection leads to increase in the expression of ribonuclease kappa (RNASEK), which is known to promote infection of viruses that rely on endocytosis and pH-dependent entry. Knockdown of RNASEK by dsRNA resulted in reduced DENV replication. Thus, increased expression of RNASEK induced by CFAV is likely to contribute to enhanced DENV replication in CFAV-infected cells. The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (DENV), West Nile virus, and yellow fever virus. These viruses are transmitted to vertebrates by mosquitoes and other arthropod species. Mosquitoes are also infected by insect-specific flaviviruses (ISFs) that do not appear to be infective to vertebrates. Cell fusing agent virus (CFAV) was the first described ISF, which was discovered in an Aedes aegypti cell culture. We found that while CFAV infection could be significantly reduced by application of RNAi against the NS5 gene, removal of the treatment led to quick restoration of CFAV replication. Interestingly, we found that CFAV infection significantly enhanced replication of DENV, and vice versa, DENV infection significantly enhanced replication of CFAV in mosquito cells. We have shown that CFAV infection leads to increase in the expression of ribonuclease kappa (RNASEK), which is known to promote infection of viruses that rely on endocytosis and pH-dependent entry. Knockdown of RNASEK by dsRNA resulted in reduced DENV replication. Thus, increased expression of RNASEK induced by CFAV is likely to contribute to enhanced DENV replication in CFAV-infected cells. Abstract The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important to humans and other vertebrates including dengue virus (DENV), West Nile virus, and yellow fever virus. These viruses are transmitted to vertebrates by mosquitoes and other arthropod species. Mosquitoes are also infected by insect-specific flaviviruses (ISFs) that do not appear to be infective to vertebrates. Cell fusing agent virus (CFAV) was the first described ISF, which was discovered in an Aedes aegypti cell culture. We found that while CFAV infection could be significantly reduced by application of RNAi against the NS5 gene, removal of the treatment led to quick restoration of CFAV replication. Interestingly, we found that CFAV infection significantly enhanced replication of DENV, and vice versa, DENV infection significantly enhanced replication of CFAV in mosquito cells. We have shown that CFAV infection leads to increase in the expression of ribonuclease kappa (RNASEK), which is known to promote infection of viruses that rely on endocytosis and pH-dependent entry. Knockdown of RNASEK by dsRNA resulted in reduced DENV replication. Thus, increased expression of RNASEK induced by CFAV is likely to contribute to enhanced DENV replication in CFAV-infected cells. |
ArticleNumber | 6935 |
Author | Khromykh, Alexander A. Asad, Sultan Zhang, Guangmei Asgari, Sassan |
Author_xml | – sequence: 1 givenname: Guangmei surname: Zhang fullname: Zhang, Guangmei organization: Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland – sequence: 2 givenname: Sultan orcidid: 0000-0001-8627-6080 surname: Asad fullname: Asad, Sultan organization: Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland – sequence: 3 givenname: Alexander A. orcidid: 0000-0001-6206-6935 surname: Khromykh fullname: Khromykh, Alexander A. organization: Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland – sequence: 4 givenname: Sassan orcidid: 0000-0001-7885-6544 surname: Asgari fullname: Asgari, Sassan email: s.asgari@uq.edu.au organization: Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland |
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Cites_doi | 10.1016/j.virol.2015.05.009 10.1371/journal.pntd.0000671 10.1099/vir.0.81475-0 10.1073/pnas.1105469108 10.1016/j.virol.2006.09.039 10.1073/pnas.1116932108 10.1073/pnas.1424098112 10.1016/0042-6822(92)90575-A 10.1099/vir.0.79850-0 10.1007/s00705-011-0967-2 10.1016/0042-6822(75)90113-0 10.3390/insects6010236 10.1007/s00705-003-0019-7 10.1016/j.meegid.2013.07.012 10.1016/j.celrep.2015.06.076 10.1073/pnas.0905006106 10.1016/j.virol.2012.02.016 10.1371/journal.ppat.1001252 10.3390/v7092851 10.1007/s00705-009-0373-1 10.1093/nar/gkm718 10.1111/j.1742-4658.2012.08526.x 10.1371/journal.pone.0056534 10.1128/JVI.00014-09 10.1155/2015/873404 10.1007/BF00919719 10.1371/journal.pntd.0003629 10.1371/journal.ppat.1000098 10.1099/vir.0.040485-0 10.4269/ajtmh.2011.10-0474 10.1146/annurev.ento.53.103106.093326 10.1099/vir.0.014183-0 10.1371/journal.pntd.0000848 10.1016/j.jviromet.2007.07.008 |
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References | CookSIsolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto RicoJ Gen Virol2006877357481:CAS:528:DC%2BD28XjsVWhtLs%3D10.1099/vir.0.81475-016528021 BollingBGEisenLMooreCGBlairCDInsect-specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmissionAm J Trop Med Hyg20118516917710.4269/ajtmh.2011.10-0474217341443122363 HoshinoKGenetic characterization of a new insect flavivirus isolated from Culex pipiens mosquito in JapanVirology20073594054141:CAS:528:DC%2BD2sXitFOms7o%3D10.1016/j.virol.2006.09.03917070886 PanXWolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegyptiProc Natl Acad Sci USA2012109E233110.1073/pnas.111693210822123956 CrabtreeMBNgaPTMillerBRIsolation and characterization of a new mosquito flavivirus, Quang Binh virus, from VietnamArch Virol20091548578601:CAS:528:DC%2BD1MXls1Slsr8%3D10.1007/s00705-009-0373-119347244 KeanJFighting arbovirus transmission: Natural and engineered control of vector competence in Aedes mosquitoesInsects2015623627810.3390/insects6010236264630784553541 KentRJCrabtreeMBMillerBRTransmission of West Nile virus by Culex quinquefasciatus Say infected with Culex flavivirus IzabalPlos Neglect. Trop. Dis20104e67110.1371/journal.pntd.0000671 Espinoza-GómezFDetection of sequences from a potentially novel strain of cell fusing agent virus in Mexican Stegomyia (Aedes) aegypti mosquitoesArch Virol20111561263126710.1007/s00705-011-0967-221409444 XiZRamirezJLDimopoulosGThe Aedes aegypti Toll pathway controls dengue virus infectionPLoS Pathog20084e100009810.1371/journal.ppat.1000098186042742435278 BollingBGOlea-PopelkaFJEisenLMooreCGBlairCDTransmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virusVirology201242790971:CAS:528:DC%2BC38Xkt1Gjsr0%3D10.1016/j.virol.2012.02.016224250623329802 BollingBGWeaverSCTeshRBVasilakisNInsect-specific virus discovery: significance for the arbovirus communityViruses20157491149281:CAS:528:DC%2BC28Xls1ynsrc%3D10.3390/v7092851263785684584295 KiritsiMNFragoulisEGSiderisDCEssential cysteine residues for human RNase k catalytic activityFEBS J2012279131813261:CAS:528:DC%2BC38XltFSltr4%3D10.1111/j.1742-4658.2012.08526.x22324914 YamanakaAThongrungkiatSRamasootaPKonishiEGenetic and evolutionary analysis of cell-fusing agent virus based on Thai strains isolated in 2008 and 2012Infect Genet Evol20131918819410.1016/j.meegid.2013.07.01223871775 Cammisa-ParksHCisarLKaneAStollarVThe complete nucleotide sequence of cell fusing agent (CFA): homology between the nonstructural proteins encoded by CFA and the nonstructural proteins encoded by arthropod-borne flavivirusesVirology19921895115241:CAS:528:DyaK3sXisVyku7k%3D10.1016/0042-6822(92)90575-A1322586 Roby, J., Hall, R. A. & Khromykh, A. A. In Molecular virology and control of flaviviruses (ed. P-Y. Shi) 21–50 (Caister Academic Press, 2012). PerreiraJMRNASEK is a V-ATPase-associated factor required for endocytosis and the replication of rhinovirus, influenza A Virus, and dengue virusCell Rep2015128508631:CAS:528:DC%2BC2MXht1Cku7vF10.1016/j.celrep.2015.06.07626212330 CalzolariMDetection of mosquito-only flaviviruses in EuropeJ Gen Virol201293121512251:CAS:528:DC%2BC38Xpt1eqsrY%3D10.1099/vir.0.040485-022377581 KiharaYRapid determination of viral RNA sequences in mosquitoes collected in the fieldJ Virol Methods20071463723741:CAS:528:DC%2BD2sXht1KrsLjM10.1016/j.jviromet.2007.07.00817869351 O’BrienCAViral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne virusesPLoS Negl Trop Dis20159e000362910.1371/journal.pntd.0003629257993914370754 StollarVThomasVLAn agent in the Aedes aegypti cell line (Peleg) which causes fusion of Aedes albopictus cellsVirology1975643673771:STN:280:DyaE2M7nvFGktQ%3D%3D10.1016/0042-6822(75)90113-0806166 EconomopoulouMAFragoulisEGSiderisDCMolecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNaseNucleic Acids Res200735638963981:CAS:528:DC%2BD2sXht1yktb3L10.1093/nar/gkm718178813632095791 HackettBARNASEK is required for internalization of diverse acid-dependent virusesProc Natl Acad Sci USA2015112779778022015PNAS..112.7797H1:CAS:528:DC%2BC2MXps1ClurY%3D10.1073/pnas.1424098112260562824485095 ScottJCComparison of Dengue virus type 2-specific small RNAs from RNA interference-competent and –incompetent mosquito cellsPLoS Negl Trop Dis20104e8482010ecas.book.....S10.1371/journal.pntd.0000848210490142964303 CookSIsolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in UgandaJ Gen Virol200990266926781:CAS:528:DC%2BD1MXhtl2qtLnM10.1099/vir.0.014183-0196569702885038 CrochuSSequences of flavivirus-related RNA viruses persist in DNA form integrated in the genome of Aedes spp. mosquitoesJ Gen Virol200485197119801:CAS:528:DC%2BD2cXlvFKhtbw%3D10.1099/vir.0.79850-015218182 HalsteadSBDengue virus-mosquito interactionsAnnu Rev Entomol2008532732911:CAS:528:DC%2BD1cXht12js7s%3D10.1146/annurev.ento.53.103106.09332617803458 PudneyMVarmaMLeakeCEstablishment of cell lines from larvae of culicine (Aedes species) and anopheline mosquitoesTCA Mannual19795997100210.1007/BF00919719 HussainMFrentiuFDMoreiraLAO’NeillSLAsgariSWolbachia utilizes host microRNAs to manipulate host gene expression and facilitate colonization of the dengue vector Aedes aegyptiProc Natl Acad Sci USA2011108925092552011PNAS..108.9250H1:CAS:528:DC%2BC3MXnsVGgurs%3D10.1073/pnas.1105469108215764693107320 LuplertlopNInduction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following infection with dengue virusPLoS Pathog20127e100125210.1371/journal.ppat.1001252 Salas-BenitoJDe Nova-OcampoMViral interference and persistence in mosquito-borne flavivirusesJ Immunol Res2015201587340410.1155/2015/873404265831584637105 Souza-NetoJASimSDimopoulosGAn evolutionary conserved function of the JAK-STAT pathway in anti-dengue defenseProc Natl Acad Sci USA200910617841178462009PNAS..10617841S1:CAS:528:DC%2BD1MXhsVSjsLnJ10.1073/pnas.0905006106198051942764916 CrabtreeMBSangRCStollarVDunsterLMMillerBRGenetic and phenotypic characterization of the newly described insect flavivirus, Kamiti River virusArch Virol2003148109511181:CAS:528:DC%2BD3sXjvVCgsLY%3D10.1007/s00705-003-0019-712756617 NasarFErasmusJHHaddowADTeshRBWeaverSCEilat virus induces both homologous and heterologous interferenceVirology201548451581:CAS:528:DC%2BC2MXoslOnt7o%3D10.1016/j.virol.2015.05.009260688854567418 Hobson-PetersJA new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cellsPLoS ONE20138e565342013PLoSO...856534H1:CAS:528:DC%2BC3sXjvV2hsL0%3D10.1371/journal.pone.0056534234608043584062 JunglenSA new favivirus and a new vector: characterization of a novel flavivirus isolated from Uranotaenia mosquitoes from a tropical rain forestJ Virol200983446244681:CAS:528:DC%2BD1MXlt1Ojsr8%3D10.1128/JVI.00014-09192249982668441 BA Hackett (7279_CR16) 2015; 112 JC Scott (7279_CR12) 2010; 4 JA Souza-Neto (7279_CR13) 2009; 106 V Stollar (7279_CR3) 1975; 64 J Salas-Benito (7279_CR7) 2015; 2015 Z Xi (7279_CR18) 2008; 4 J Kean (7279_CR8) 2015; 6 MB Crabtree (7279_CR19) 2003; 148 A Yamanaka (7279_CR5) 2013; 19 J Hobson-Peters (7279_CR27) 2013; 8 BG Bolling (7279_CR28) 2012; 427 JM Perreira (7279_CR17) 2015; 12 S Cook (7279_CR4) 2006; 87 M Hussain (7279_CR11) 2011; 108 K Hoshino (7279_CR21) 2007; 359 SB Halstead (7279_CR2) 2008; 53 F Espinoza-Gómez (7279_CR31) 2011; 156 S Junglen (7279_CR23) 2009; 83 BG Bolling (7279_CR24) 2011; 85 7279_CR1 H Cammisa-Parks (7279_CR33) 1992; 189 S Crochu (7279_CR6) 2004; 85 M Pudney (7279_CR9) 1979; 5 M Calzolari (7279_CR25) 2012; 93 F Nasar (7279_CR26) 2015; 484 BG Bolling (7279_CR29) 2015; 7 MA Economopoulou (7279_CR34) 2007; 35 Y Kihara (7279_CR32) 2007; 146 MB Crabtree (7279_CR20) 2009; 154 RJ Kent (7279_CR30) 2010; 4 X Pan (7279_CR14) 2012; 109 MN Kiritsi (7279_CR35) 2012; 279 CA O’Brien (7279_CR10) 2015; 9 N Luplertlop (7279_CR15) 2012; 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References_xml | – volume: 484 start-page: 51 year: 2015 ident: 7279_CR26 publication-title: Virology doi: 10.1016/j.virol.2015.05.009 contributor: fullname: F Nasar – volume: 4 start-page: e671 year: 2010 ident: 7279_CR30 publication-title: Plos Neglect. Trop. Dis doi: 10.1371/journal.pntd.0000671 contributor: fullname: RJ Kent – volume: 87 start-page: 735 year: 2006 ident: 7279_CR4 publication-title: J Gen Virol doi: 10.1099/vir.0.81475-0 contributor: fullname: S Cook – volume: 108 start-page: 9250 year: 2011 ident: 7279_CR11 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1105469108 contributor: fullname: M Hussain – volume: 359 start-page: 405 year: 2007 ident: 7279_CR21 publication-title: Virology doi: 10.1016/j.virol.2006.09.039 contributor: fullname: K Hoshino – volume: 109 start-page: E23 year: 2012 ident: 7279_CR14 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1116932108 contributor: fullname: X Pan – volume: 112 start-page: 7797 year: 2015 ident: 7279_CR16 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1424098112 contributor: fullname: BA Hackett – volume: 189 start-page: 511 year: 1992 ident: 7279_CR33 publication-title: Virology doi: 10.1016/0042-6822(92)90575-A contributor: fullname: H Cammisa-Parks – volume: 85 start-page: 1971 year: 2004 ident: 7279_CR6 publication-title: J Gen Virol doi: 10.1099/vir.0.79850-0 contributor: fullname: S Crochu – volume: 156 start-page: 1263 year: 2011 ident: 7279_CR31 publication-title: Arch Virol doi: 10.1007/s00705-011-0967-2 contributor: fullname: F Espinoza-Gómez – volume: 64 start-page: 367 year: 1975 ident: 7279_CR3 publication-title: Virology doi: 10.1016/0042-6822(75)90113-0 contributor: fullname: V Stollar – volume: 6 start-page: 236 year: 2015 ident: 7279_CR8 publication-title: Insects doi: 10.3390/insects6010236 contributor: fullname: J Kean – volume: 148 start-page: 1095 year: 2003 ident: 7279_CR19 publication-title: Arch Virol doi: 10.1007/s00705-003-0019-7 contributor: fullname: MB Crabtree – volume: 19 start-page: 188 year: 2013 ident: 7279_CR5 publication-title: Infect Genet Evol doi: 10.1016/j.meegid.2013.07.012 contributor: fullname: A Yamanaka – volume: 12 start-page: 850 year: 2015 ident: 7279_CR17 publication-title: Cell Rep doi: 10.1016/j.celrep.2015.06.076 contributor: fullname: JM Perreira – volume: 106 start-page: 17841 year: 2009 ident: 7279_CR13 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0905006106 contributor: fullname: JA Souza-Neto – volume: 427 start-page: 90 year: 2012 ident: 7279_CR28 publication-title: Virology doi: 10.1016/j.virol.2012.02.016 contributor: fullname: BG Bolling – volume: 7 start-page: e1001252 year: 2012 ident: 7279_CR15 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1001252 contributor: fullname: N Luplertlop – volume: 7 start-page: 4911 year: 2015 ident: 7279_CR29 publication-title: Viruses doi: 10.3390/v7092851 contributor: fullname: BG Bolling – volume: 154 start-page: 857 year: 2009 ident: 7279_CR20 publication-title: Arch Virol doi: 10.1007/s00705-009-0373-1 contributor: fullname: MB Crabtree – volume: 35 start-page: 6389 year: 2007 ident: 7279_CR34 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm718 contributor: fullname: MA Economopoulou – volume: 279 start-page: 1318 year: 2012 ident: 7279_CR35 publication-title: FEBS J doi: 10.1111/j.1742-4658.2012.08526.x contributor: fullname: MN Kiritsi – volume: 8 start-page: e56534 year: 2013 ident: 7279_CR27 publication-title: PLoS ONE doi: 10.1371/journal.pone.0056534 contributor: fullname: J Hobson-Peters – volume: 83 start-page: 4462 year: 2009 ident: 7279_CR23 publication-title: J Virol doi: 10.1128/JVI.00014-09 contributor: fullname: S Junglen – volume: 2015 start-page: 873404 year: 2015 ident: 7279_CR7 publication-title: J Immunol Res doi: 10.1155/2015/873404 contributor: fullname: J Salas-Benito – volume: 5 start-page: 997 year: 1979 ident: 7279_CR9 publication-title: TCA Mannual doi: 10.1007/BF00919719 contributor: fullname: M Pudney – volume: 9 start-page: e0003629 year: 2015 ident: 7279_CR10 publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0003629 contributor: fullname: CA O’Brien – volume: 4 start-page: e1000098 year: 2008 ident: 7279_CR18 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000098 contributor: fullname: Z Xi – ident: 7279_CR1 – volume: 93 start-page: 1215 year: 2012 ident: 7279_CR25 publication-title: J Gen Virol doi: 10.1099/vir.0.040485-0 contributor: fullname: M Calzolari – volume: 85 start-page: 169 year: 2011 ident: 7279_CR24 publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2011.10-0474 contributor: fullname: BG Bolling – volume: 53 start-page: 273 year: 2008 ident: 7279_CR2 publication-title: Annu Rev Entomol doi: 10.1146/annurev.ento.53.103106.093326 contributor: fullname: SB Halstead – volume: 90 start-page: 2669 year: 2009 ident: 7279_CR22 publication-title: J Gen Virol doi: 10.1099/vir.0.014183-0 contributor: fullname: S Cook – volume: 4 start-page: e848 year: 2010 ident: 7279_CR12 publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0000848 contributor: fullname: JC Scott – volume: 146 start-page: 372 year: 2007 ident: 7279_CR32 publication-title: J Virol Methods doi: 10.1016/j.jviromet.2007.07.008 contributor: fullname: Y Kihara |
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Snippet | The genus
Flavivirus
contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important... The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically important... Abstract The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-borne RNA viruses. Some flaviviruses are particularly medically... |
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SubjectTerms | 631/326/596/1413 631/326/596/2557 Aedes - cytology Aedes - virology Aedes aegypti Animals Aquatic insects Cell culture Cell Line Cell lines Cercopithecus aethiops Dengue - virology Dengue fever Dengue Virus - isolation & purification Dengue Virus - pathogenicity Disease transmission Double-stranded RNA Endocytosis Endoribonucleases - metabolism Fever Flavivirus - classification Flavivirus - isolation & purification Flavivirus - pathogenicity Humanities and Social Sciences Infections Mosquitoes multidisciplinary pH effects Phylogeny Replication Ribonuclease RNA Interference RNA viruses RNA-mediated interference Science Science (multidisciplinary) Vector-borne diseases Vero Cells Vertebrates Viral Nonstructural Proteins - genetics Virus Replication Viruses West Nile virus |
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Title | Cell fusing agent virus and dengue virus mutually interact in Aedes aegypti cell lines |
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