Sedentary behavior as a risk factor for cognitive decline: A focus on the influence of glycemic control in brain health

Abstract Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend most...

Full description

Saved in:
Bibliographic Details
Published inAlzheimer's & dementia : translational research & clinical interventions Vol. 3; no. 3; pp. 291 - 300
Main Authors Wheeler, Michael J, Dempsey, Paddy C, Grace, Megan S, Ellis, Kathryn A, Gardiner, Paul A, Green, Daniel J, Dunstan, David W
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2017
John Wiley & Sons, Inc
Elsevier
Subjects
Alzheimer's disease
Apoptosis
Brain research
Breaks in sedentary time
Chronic illnesses
Cognitive function
Dementia
Diabetes
Energy
Exercise
Glucose
Glucose metabolism
Hyperglycemia
Hypoglycemia
Insulin resistance
Investigations
Light-intensity activity
Metabolism
Neurology
Neuropathology
Older people
Other
Physical activity
Public health
Sedentary behavior
Sitting
United States > US
Glucose metabolism
Sedentary behavior
Exercise
Physical activity
Sitting
Light-intensity activity
Breaks in sedentary time
Diabetes
Cognitive function
Alzheimer's disease
Dementia
Online AccessGet full text

Cover

Abstract Abstract Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend most of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, an additional practical strategy may be to reduce and replace sedentary behavior with intermittent light-intensity physical activity. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing sedentary behavior can help slow cognitive decline.
AbstractList Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all‐cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light‐intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline. Highlights Older adults spend a majority of time in sedentary behavior. Sedentary behavior may be linked to cognitive decline via glycemic control. Replacing sitting with intermittent light activity can improve glycemic control. Future research should determine if light activity can forestall cognitive decline. Engaging in more light activity may be an achievable public health target.
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all‐cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light‐intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline. Older adults spend a majority of time in sedentary behavior. Sedentary behavior may be linked to cognitive decline via glycemic control. Replacing sitting with intermittent light activity can improve glycemic control. Future research should determine if light activity can forestall cognitive decline. Engaging in more light activity may be an achievable public health target.
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline. • Older adults spend a majority of time in sedentary behavior. • Sedentary behavior may be linked to cognitive decline via glycemic control. • Replacing sitting with intermittent light activity can improve glycemic control. • Future research should determine if light activity can forestall cognitive decline. • Engaging in more light activity may be an achievable public health target.
Abstract Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend most of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, an additional practical strategy may be to reduce and replace sedentary behavior with intermittent light-intensity physical activity. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing sedentary behavior can help slow cognitive decline.
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline. •Older adults spend a majority of time in sedentary behavior.•Sedentary behavior may be linked to cognitive decline via glycemic control.•Replacing sitting with intermittent light activity can improve glycemic control.•Future research should determine if light activity can forestall cognitive decline.•Engaging in more light activity may be an achievable public health target.
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all‐cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light‐intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.
Author Grace, Megan S.
Dunstan, David W.
Dempsey, Paddy C.
Green, Daniel J.
Wheeler, Michael J.
Gardiner, Paul A.
Ellis, Kathryn A.
AuthorAffiliation f Centre for Health Services Research, The University of Queensland, South Brisbane, Queensland, Australia
i Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia
d Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
a Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
c Swinburne University of Technology, Melbourne, Victoria, Australia
e The Florey Institute of Neuroscience and Mental Health, The University of Melbourne Parkville, Parkville, Victoria, Australia
h Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
b School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia
g Mater Research Institute, The University of Queensland, South Brisbane, Queensland, Australia
AuthorAffiliation_xml – name: a Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
– name: b School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia
– name: d Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
– name: c Swinburne University of Technology, Melbourne, Victoria, Australia
– name: e The Florey Institute of Neuroscience and Mental Health, The University of Melbourne Parkville, Parkville, Victoria, Australia
– name: f Centre for Health Services Research, The University of Queensland, South Brisbane, Queensland, Australia
– name: g Mater Research Institute, The University of Queensland, South Brisbane, Queensland, Australia
– name: h Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
– name: i Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia
Author_xml – sequence: 1
  fullname: Wheeler, Michael J
– sequence: 2
  fullname: Dempsey, Paddy C
– sequence: 3
  fullname: Grace, Megan S
– sequence: 4
  fullname: Ellis, Kathryn A
– sequence: 5
  fullname: Gardiner, Paul A
– sequence: 6
  fullname: Green, Daniel J
– sequence: 7
  fullname: Dunstan, David W
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29067335$$D View this record in MEDLINE/PubMed
BookMark eNqNUk1rGzEQXUpKk7r5Az0UQS-92NXHSrsuJZCafqQECo3vQqsdxXJkKZW0Dv731eIkpD6EHjQSM-89ZjTvdXXkg4eqekvwjGAiPq5nOWo7o5g0M1zPMCYvqhPKOJ22DWuOnryPq9OU1rggOG3njL-qjukci4YxflLdXUEPPqu4Qx2s1NaGiFRCCkWbbpBROpeEKUeHa2-z3QLqQTvr4RM6LwU9JBQ8yitA1hs3gNeAgkHXbqdhY3Xh-RyDK1XURVXiCpTLqzfVS6NcgtP7e1Itv31dLn5ML399v1icX061wIJMO1pjMJrqXtCurzXrVBkJN7jveqFEJ_pWK2O4abmiRs9rwkQjFBGkrYEAm1Rne9nbodtAr8uoUTl5G-2mjCyDsvLfircreR22kgtOatIWgQ_3AjH8GSBlubFJg3PKQxiSJHPOBaO0dDWp3h9A12GIvkwnKeeUsIZgXFDvnnb02MrDSgqg3QN0DClFMFLbrLId_1FZJwmWowHkWo4GkKMBJK5lWW-h0gPqg_qzpC970p11sPsPhlz-XtCfJVyMSVzvRT7vRaDscmshyqTt6IXeRtBZ9sE-38PZAX20mNXK3cAO0uM_EpmoxPJq9PZobVK8gCmn7C-U2_Or
CitedBy_id crossref_primary_10_1136_bmjopen_2021_050458
crossref_primary_10_1007_s00421_023_05278_1
crossref_primary_10_1016_j_physbeh_2024_114744
crossref_primary_10_36660_ijcs_20200050
crossref_primary_10_1016_j_maturitas_2020_10_011
crossref_primary_10_1038_s41598_020_70679_7
crossref_primary_10_2147_CIA_S326686
crossref_primary_10_3389_fpubh_2018_00372
crossref_primary_10_1016_j_bbr_2022_113926
crossref_primary_10_1136_bmjopen_2020_046077
crossref_primary_10_3389_fnhum_2020_00307
crossref_primary_10_1097_NNR_0000000000000749
crossref_primary_10_3389_fnhum_2020_00273
crossref_primary_10_1016_j_mhpa_2018_05_003
crossref_primary_10_3390_healthcare10040737
crossref_primary_10_36660_ijcs_20200209
crossref_primary_10_1002_wps_21188
crossref_primary_10_1016_j_tics_2024_02_003
crossref_primary_10_1590_0102_311x00076621
crossref_primary_10_3389_frym_2019_00077
crossref_primary_10_3233_JAD_230575
crossref_primary_10_1080_02640414_2018_1486362
crossref_primary_10_1186_s13195_020_00644_z
crossref_primary_10_1017_jns_2024_91
crossref_primary_10_1186_s40035_023_00364_y
crossref_primary_10_1007_s10571_020_01024_9
crossref_primary_10_1016_j_neurobiolaging_2023_11_004
crossref_primary_10_4103_jehp_jehp_1773_23
crossref_primary_10_55905_cuadv17n2_121
crossref_primary_10_1038_s41598_022_23706_8
crossref_primary_10_1016_S2213_8587_18_30136_0
crossref_primary_10_1249_MSS_0000000000002374
crossref_primary_10_3389_fpsyg_2023_1092804
crossref_primary_10_1111_aphw_12318
crossref_primary_10_1186_s12877_021_02054_8
crossref_primary_10_3389_fnhum_2023_1282728
crossref_primary_10_3389_fncel_2022_1007166
crossref_primary_10_3389_fpubh_2024_1446286
crossref_primary_10_1007_s11682_021_00534_4
crossref_primary_10_1177_26331055241285880
crossref_primary_10_1186_s12877_018_0852_x
crossref_primary_10_1152_japplphysiol_00001_2019
crossref_primary_10_1080_02640414_2020_1847478
crossref_primary_10_1016_j_advnut_2024_100343
crossref_primary_10_1038_s41569_021_00547_y
crossref_primary_10_1177_20552076241241509
crossref_primary_10_1007_s40279_019_01186_7
crossref_primary_10_1016_j_ijpsycho_2025_112519
crossref_primary_10_1152_japplphysiol_00310_2018
crossref_primary_10_1093_ajcn_nqy346
crossref_primary_10_3233_WOR_230624
crossref_primary_10_52547_ijwph_12_4_271
crossref_primary_10_1038_s41598_025_86039_2
crossref_primary_10_1152_physrev_00022_2020
crossref_primary_10_3390_su13126806
crossref_primary_10_1093_geronb_gbz087
crossref_primary_10_1152_physrev_00022_2022
crossref_primary_10_1186_s12877_020_01827_x
crossref_primary_10_5114_pq_2023_117072
crossref_primary_10_1007_s00520_018_4459_8
crossref_primary_10_1038_s41598_025_93149_4
crossref_primary_10_1080_23748834_2024_2314382
crossref_primary_10_1016_j_euroneuro_2022_07_574
crossref_primary_10_1016_j_mhpa_2017_11_001
crossref_primary_10_3928_19404921_20211021_01
crossref_primary_10_1016_j_bbr_2019_112358
crossref_primary_10_1038_s41398_020_0799_5
crossref_primary_10_1007_s40520_020_01531_1
crossref_primary_10_1371_journal_pone_0219565
crossref_primary_10_1007_s00421_022_04978_4
crossref_primary_10_1007_s11357_020_00276_z
crossref_primary_10_1111_psyp_13830
crossref_primary_10_3389_fcimb_2020_00104
crossref_primary_10_1016_j_arr_2022_101804
crossref_primary_10_2174_0113816128244442231018070639
crossref_primary_10_4103_jiag_jiag_49_24
crossref_primary_10_1113_JP287099
crossref_primary_10_1016_j_clnu_2020_10_006
crossref_primary_10_1136_jech_2019_213029
crossref_primary_10_3389_fnagi_2018_00341
crossref_primary_10_1146_annurev_publhealth_052620_091107
crossref_primary_10_2196_55079
crossref_primary_10_1186_s40798_022_00507_x
crossref_primary_10_2139_ssrn_4121725
crossref_primary_10_3233_WOR_205315
crossref_primary_10_1038_s41598_022_18248_y
crossref_primary_10_18632_aging_204668
crossref_primary_10_1590_0102_311xen046523
crossref_primary_10_2174_1567205020666230811092956
crossref_primary_10_1177_08982643251318766
crossref_primary_10_1007_s11332_021_00753_8
crossref_primary_10_1177_0271678X211009382
crossref_primary_10_1111_psyp_13457
crossref_primary_10_3389_fnhum_2021_719509
crossref_primary_10_1186_s13063_023_07407_9
crossref_primary_10_1111_joid_12212
crossref_primary_10_3390_ijerph18147649
crossref_primary_10_1016_j_pmedr_2021_101423
crossref_primary_10_1152_physrev_00050_2017
crossref_primary_10_1038_s41598_020_72098_0
crossref_primary_10_1016_j_mhpa_2022_100481
crossref_primary_10_3233_ADR_220088
crossref_primary_10_1186_s12891_021_04136_5
crossref_primary_10_1186_s12889_020_08620_w
crossref_primary_10_3390_ijms251910757
crossref_primary_10_3390_su12176751
crossref_primary_10_3390_nu16020203
crossref_primary_10_1192_bjp_2019_60
crossref_primary_10_1093_gerona_glab013
crossref_primary_10_1249_MSS_0000000000002113
crossref_primary_10_2188_jea_JE20190141
crossref_primary_10_2337_dc20_2850
crossref_primary_10_1002_dad2_12569
crossref_primary_10_3390_ijerph19031357
crossref_primary_10_1038_s41598_019_39354_4
crossref_primary_10_1186_s12974_020_01935_w
Cites_doi 10.1007/s11892-016-0797-4
10.3390/ijms131012629
10.1016/j.resp.2012.07.014
10.1136/bmjopen-2015-009630
10.1038/srep32044
10.1152/physrev.1997.77.3.731
10.1093/eurheartj/ehq451
10.1016/j.brainresrev.2007.01.003
10.1056/NEJMoa1215740
10.1016/j.jagp.2013.01.060
10.3389/fneur.2015.00187
10.1136/bjsports-2015-095551
10.1002/glia.22667
10.1249/MSS.0b013e318213fefb
10.1038/nature09613
10.1038/nm.2052
10.2337/diacare.23.2.163
10.1126/science.7027439
10.1055/s-2007-978997
10.1001/jama.2012.116975
10.1007/s11892-014-0522-0
10.1111/j.1445-5994.2012.02758.x
10.1016/j.jalz.2012.11.007
10.1001/archneurol.2010.225
10.1016/j.brainresrev.2007.05.011
10.1016/j.jns.2009.10.022
10.1139/h2012-024
10.1056/NEJMra1215228
10.1007/s00125-016-4161-7
10.1016/j.jagp.2012.12.026
10.1046/j.1471-4159.2000.0740001.x
10.1038/380168a0
10.1038/jcbfm.2009.206
10.1016/S0140-6736(16)30370-1
10.2337/db14-1729
10.1016/j.jalz.2012.11.006
10.1136/bjsports-2015-095699
10.1016/S1474-4422(11)70188-0
10.2337/dc10-0389
10.7326/M14-1651
10.1073/pnas.1108225109
10.1007/s00125-016-4180-4
10.2337/diab.40.2.223
10.1016/j.jsams.2016.09.015
10.2353/ajpath.2007.070050
10.1002/jnr.20654
10.1016/j.ypmed.2016.05.009
10.1249/MSS.0000000000000654
10.1016/S2213-8587(14)70148-2
10.1016/S0140-6736(12)60646-1
10.1001/jama.2009.460
10.1016/j.jalz.2007.04.381
10.1113/jphysiol.2005.091355
10.1073/pnas.91.20.9352
ContentType Journal Article
Copyright The Authors
2017 The Authors
2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2017 The Authors 2017
Copyright_xml – notice: The Authors
– notice: 2017 The Authors
– notice: 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
– notice: 2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2017 The Authors 2017
DBID 6I.
AAFTH
24P
AAYXX
CITATION
NPM
3V.
7RV
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
KB0
M0S
NAPCQ
PHGZM
PHGZT
PIMPY
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1016/j.trci.2017.04.001
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Wiley-Blackwell Open Access Titles
CrossRef
PubMed
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Central (New)
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef


MEDLINE - Academic

Publicly Available Content Database
PubMed
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley Online Library Open Access (WRLC)
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Public Health
EISSN 2352-8737
EndPage 300
ExternalDocumentID PMC5651418
29067335
10_1016_j_trci_2017_04_001
TRC2JTRCI201704001
S2352873717300252
1_s2_0_S2352873717300252
Genre shortArticle
Journal Article
Review
GeographicLocations United States--US
GeographicLocations_xml – name: United States--US
GrantInformation_xml – fundername: University of Melbourne
– fundername: National Health and Medical Research Council of Australia (NHMRC)
  funderid: 1062338
– fundername: Victorian Government's Operational Infrastructure Support Program
– fundername: NHMRC Principal Research Fellowship
  funderid: APP1080914
– fundername: University of Western Australia and the Baker Heart and Diabetes Institute
– fundername: Swinburne University, Melbourne, Australia
– fundername: Baker Heart and Diabetes Institute Flack Fellowship
– fundername: NHMRC Senior Research Fellowship
  funderid: APP1078360
– fundername: NHMRC and Australian Research Council (ARC) joint Dementia Research Development Fellowship
  funderid: APP1103311
– fundername: Medical Research Council
  grantid: MC_UU_12015/3
GroupedDBID 0R~
0SF
1OC
24P
457
53G
6I.
7RV
7X7
8FI
8FJ
AACTN
AAEDW
AAFTH
AAHHS
AALRI
AAXUO
ABMAC
ABUWG
ACCFJ
ACCMX
ACGFS
ACXQS
ADBBV
ADEZE
ADKYN
ADPDF
ADVLN
ADZMN
ADZOD
AEEZP
AEQDE
AEVXI
AEXQZ
AFKRA
AFTJW
AGHFR
AITUG
AIWBW
AJBDE
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMRAJ
AOIJS
AVUZU
BENPR
CCPQU
EBS
EJD
EMOBN
FDB
FYUFA
GROUPED_DOAJ
HMCUK
HYE
IAO
IHR
INH
ITC
KQ8
M~E
NAPCQ
NCXOZ
O9-
OK1
OVD
OVEED
PIMPY
ROL
RPM
SSZ
TEORI
UKHRP
WIN
AAYWO
AAYXX
CITATION
PHGZM
PHGZT
NPM
PPXIY
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c6061-b240efc2cd62bd4c3ba873070dbd6a6b6d8caff5f85a2fc9413676a16184e1e3
IEDL.DBID 7X7
ISSN 2352-8737
IngestDate Thu Aug 21 17:37:57 EDT 2025
Fri Jul 11 00:05:58 EDT 2025
Wed Aug 13 08:13:47 EDT 2025
Mon Jul 21 06:04:06 EDT 2025
Tue Jul 01 04:07:36 EDT 2025
Thu Apr 24 23:11:10 EDT 2025
Wed Jan 22 16:37:34 EST 2025
Fri Feb 23 02:28:53 EST 2024
Tue Feb 25 19:56:00 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Glucose metabolism
Sedentary behavior
Exercise
Physical activity
Sitting
Light-intensity activity
Breaks in sedentary time
Diabetes
Cognitive function
Alzheimer's disease
Dementia
Language English
License This is an open access article under the CC BY-NC-ND license.
Attribution-NonCommercial-NoDerivs
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c6061-b240efc2cd62bd4c3ba873070dbd6a6b6d8caff5f85a2fc9413676a16184e1e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.proquest.com/docview/2552137100?pq-origsite=%requestingapplication%
PMID 29067335
PQID 2552137100
PQPubID 5066177
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5651418
proquest_miscellaneous_1955632287
proquest_journals_2552137100
pubmed_primary_29067335
crossref_citationtrail_10_1016_j_trci_2017_04_001
crossref_primary_10_1016_j_trci_2017_04_001
wiley_primary_10_1016_j_trci_2017_04_001_TRC2JTRCI201704001
elsevier_sciencedirect_doi_10_1016_j_trci_2017_04_001
elsevier_clinicalkeyesjournals_1_s2_0_S2352873717300252
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate September 2017
PublicationDateYYYYMMDD 2017-09-01
PublicationDate_xml – month: 09
  year: 2017
  text: September 2017
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle Alzheimer's & dementia : translational research & clinical interventions
PublicationTitleAlternate Alzheimers Dement (N Y)
PublicationYear 2017
Publisher Elsevier Inc
John Wiley & Sons, Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: John Wiley & Sons, Inc
– name: Elsevier
References Benatti, Ried-Larsen (bib13) 2015; 47
Wimo, Jönsson, Bond, Prince, Winblad (bib2) 2013; 9
Keadle, McKinnon, Graubard, Troiano (bib8) 2016; 89
Longo, Cryer (bib28) 2013; 369
Prince, Bryce, Albanese, Wimo, Ribeiro, Ferri (bib1) 2013; 9
Healy, Matthews, Dunstan, Winkler, Owen (bib45) 2011; 32
Wyke (bib20) 1958; 11
Wennberg, Boraxbekk, Wheeler, Howard, Dempsey, Lambert (bib52) 2016; 6
Hallal, Andersen, Bull, Guthold, Haskell, Ekelund (bib7) 2012; 380
Mergenthaler, Kahl, Kamitz, van Laak, Stohlmann, Thomsen (bib24) 2012; 109
Rizzo, Marfella, Barbieri, Boccardi, Vestini, Lettieri (bib43) 2010; 33
Shah, DeSilva, Abbruscato (bib16) 2012; 13
Biswas, Oh, Faulkner, Bajaj, Silver, Mitchell (bib11) 2015; 162
Garber, Blissmer, Deschenes, Franklin, Lamonte, Lee (bib6) 2011; 43
Dempsey, Grace, Dunstan (bib49) 2017; 60
Cox, Gonder-Frederick, Kovatchev, Julian, Clarke (bib22) 2000; 23
Smith, Wong, Eves, Koelwyn, Smirl, Willie (bib51) 2012; 184
Scherder, Scherder, Verburgh, Konigs, Blom, Kramer (bib55) 2014; 22
Attwell, Buchan, Charpak, Lauritzen, MacVicar, Newman (bib32) 2010; 468
Wilhelmus, Otte-Holler, van Triel, Veerhuis, Maat-Schieman, Bu (bib38) 2007; 171
Farkas, Luiten, Bari (bib36) 2007; 54
Page, Chan, Arora, Belfort-Deaguiar, Dzuira, Roehmholdt (bib33) 2013; 309
Busija, Bari, Domoki, Louis (bib31) 2007; 56
Bergouignan, Latouche, Heywood, Grace, Reddy-Luthmoodoo, Natoli (bib46) 2016; 6
Nijland, Michailidou, Witte, Mizee, Van Der Pol, Van Het Hof (bib15) 2014; 62
Ball, Cruz, Mrak, Dienel (bib37) 2010; 30
Rolfe, Brown (bib14) 1997; 77
Criego, Tkac, Kumar, Thomas, Gruetter, Seaquist (bib30) 2005; 82
Cheng, Huang, Deng, Wang (bib17) 2012; 42
Cryer (bib26) 1997; 29
Launer, Miller, Williamson, Lazar, Gerstein, Murray (bib42) 2011; 10
Brookmeyer, Johnson, Ziegler-Graham, Arrighi (bib3) 2007; 3
Sastry, Rao (bib25) 2000; 74
Heller, Cryer (bib27) 1991; 40
Zheng, Xia, Zhou, Tao, Chen (bib5) 2016; 50
Cheng, Chow, Song, Yu, Chan, Lee (bib54) 2014; 22
Dempsey, Owen, Biddle, Dunstan (bib9) 2014; 14
(bib44) 2012; 37
Crane, Walker, Hubbard, Li, Nathan, Zheng (bib18) 2013; 369
Baker, Cross, Minoshima, Belongia, Watson, Craft (bib19) 2011; 68
Mullane, Buman, Zeigler, Crespo, Gaesser (bib53) 2016; 20
Whitmer, Karter, Yaffe, Quesenberry, Selby (bib23) 2009; 301
Thomas, Thomas, McLendon, Sutton, Mullan (bib39) 1996; 380
Joy, Tate, Younk, Davis (bib34) 2015; 64
Jensen, Hasselbalch, Waldemar, Simonsen (bib4) 2015; 6
Duvivier, Schaper, Hesselink, van Kan, Stienen, Winkens (bib48) 2017; 60
Geraldes, Hiraoka-Yamamoto, Matsumoto, Clermont, Leitges, Marette (bib35) 2009; 15
Geijselaers, Sep, Stehouwer, Biessels (bib41) 2015; 3
Dempsey, Owen, Yates, Kingwell, Dunstan (bib47) 2016; 16
Gjedde, Crone (bib21) 1981; 214
Ekelund, Steene-Johannessen, Brown, Fagerland, Owen, Powell (bib10) 2016; 388
Kemppainen, Aalto, Fujimoto, Kalliokoski, Langsjo, Oikonen (bib50) 2005; 568
Boyle, Nagy, O'Connor, Kempers, Yeo, Qualls (bib29) 1994; 91
Hanyu, Sato, Hirao, Kanetaka, Iwamoto, Koizumi (bib40) 2010; 290
Falck, Davis, Liu-Ambrose (bib12) 2017; 51
2010; 468
2013; 369
1958; 11
2016; 388
1996; 380
2011; 10
2014; 62
2012; 13
2014; 22
2013; 9
2015; 47
2007; 171
1991; 40
2014; 14
2011; 68
2007; 3
2010; 30
2009; 15
2016; 89
2015; 162
2010; 33
2012; 184
2015; 6
2017; 60
2015; 3
2000; 23
2013; 309
2012; 380
1997; 29
2011; 32
2016; 50
2005; 82
2012; 37
2007; 54
2016; 16
2007; 56
2012; 109
2017; 51
2016; 6
1997; 77
1981; 214
2015; 64
2000; 74
2005; 568
2016; 20
2011; 43
1994; 91
2010; 290
2009; 301
2012; 42
e_1_2_14_31_1
e_1_2_14_52_1
e_1_2_14_50_1
e_1_2_14_10_1
e_1_2_14_35_1
e_1_2_14_56_1
e_1_2_14_12_1
e_1_2_14_33_1
e_1_2_14_14_1
e_1_2_14_39_1
e_1_2_14_16_1
e_1_2_14_37_1
e_1_2_14_6_1
e_1_2_14_8_1
e_1_2_14_41_1
e_1_2_14_20_1
e_1_2_14_4_1
e_1_2_14_45_1
e_1_2_14_24_1
e_1_2_14_43_1
e_1_2_14_22_1
Prince M. (e_1_2_14_2_1) 2013; 9
e_1_2_14_28_1
e_1_2_14_49_1
e_1_2_14_26_1
Longo D.L. (e_1_2_14_29_1) 2013; 369
e_1_2_14_47_1
e_1_2_14_19_1
e_1_2_14_30_1
e_1_2_14_53_1
e_1_2_14_51_1
e_1_2_14_11_1
e_1_2_14_34_1
e_1_2_14_13_1
e_1_2_14_32_1
e_1_2_14_55_1
e_1_2_14_15_1
e_1_2_14_38_1
e_1_2_14_17_1
e_1_2_14_36_1
e_1_2_14_5_1
e_1_2_14_7_1
e_1_2_14_9_1
e_1_2_14_42_1
e_1_2_14_3_1
e_1_2_14_40_1
e_1_2_14_23_1
e_1_2_14_46_1
e_1_2_14_44_1
e_1_2_14_27_1
e_1_2_14_25_1
e_1_2_14_48_1
e_1_2_14_18_1
Wyke B.D. (e_1_2_14_21_1) 1958; 11
Mullane S.L. (e_1_2_14_54_1) 2016; 20
References_xml – volume: 309
  start-page: 63
  year: 2013
  end-page: 70
  ident: bib33
  article-title: Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
  publication-title: JAMA
– volume: 369
  start-page: 540
  year: 2013
  end-page: 548
  ident: bib18
  article-title: Glucose levels and risk of dementia
  publication-title: N Engl J Med
– volume: 62
  start-page: 1125
  year: 2014
  end-page: 1141
  ident: bib15
  article-title: Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
  publication-title: Glia
– volume: 30
  start-page: 162
  year: 2010
  end-page: 176
  ident: bib37
  article-title: Trafficking of glucose, lactate, and amyloid-β from the inferior colliculus through perivascular routes
  publication-title: J Cereb Blood Flow Metab
– volume: 43
  start-page: 1334
  year: 2011
  end-page: 1359
  ident: bib6
  article-title: American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise
  publication-title: Med Sci Sports Exerc
– volume: 89
  start-page: 37
  year: 2016
  end-page: 43
  ident: bib8
  article-title: Prevalence and trends in physical activity among older adults in the United States: a comparison across three national surveys
  publication-title: Prev Med (Baltim)
– volume: 10
  start-page: 969
  year: 2011
  end-page: 977
  ident: bib42
  article-title: Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
  publication-title: Lancet Neurol
– volume: 6
  start-page: 187
  year: 2015
  ident: bib4
  article-title: Biochemical markers of physical exercise on mild cognitive impairment and dementia: systematic review and perspectives
  publication-title: Front Neurol
– volume: 162
  start-page: 123
  year: 2015
  ident: bib11
  article-title: Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults
  publication-title: Ann Intern Med
– volume: 23
  start-page: 163
  year: 2000
  end-page: 170
  ident: bib22
  article-title: Progressive hypoglycemia’s impact on driving simulation performance. Occurrence, awareness and correction
  publication-title: Diabetes Care
– volume: 77
  start-page: 731
  year: 1997
  end-page: 758
  ident: bib14
  article-title: Cellular energy utilization and molecular origin of standard metabolic rate in mammals
  publication-title: Physiol Rev
– volume: 32
  start-page: 590
  year: 2011
  end-page: 597
  ident: bib45
  article-title: Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 200306
  publication-title: Eur Heart J
– volume: 60
  start-page: 390
  year: 2017
  end-page: 394
  ident: bib49
  article-title: Adding exercise or subtracting sitting time for glycemic control: where do we stand?
  publication-title: Diabetologia
– volume: 20
  start-page: 489
  year: 2016
  end-page: 493
  ident: bib53
  article-title: Acute effects on cognitive performance following bouts of standing and light-intensity physical activity in a simulated workplace environment
  publication-title: J Sci Med Sport
– volume: 42
  start-page: 484
  year: 2012
  end-page: 491
  ident: bib17
  article-title: Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
  publication-title: Intern Med J
– volume: 9
  year: 2013
  ident: bib1
  article-title: The global prevalence of dementia: a systematic review and metaanalysis
  publication-title: Alzheimers Dement
– volume: 380
  start-page: 247
  year: 2012
  end-page: 257
  ident: bib7
  article-title: Global physical activity levels: surveillance progress, pitfalls, and prospects
  publication-title: Lancet
– volume: 50
  start-page: 1443
  year: 2016
  ident: bib5
  article-title: Aerobic exercise ameliorates cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomised controlled trials
  publication-title: Br J Sports Med
– volume: 369
  start-page: 362
  year: 2013
  end-page: 372
  ident: bib28
  article-title: Mechanisms of hypoglycemia-associated autonomic failure in diabetes
  publication-title: N Engl J Med
– volume: 568
  start-page: 323
  year: 2005
  end-page: 332
  ident: bib50
  article-title: High intensity exercise decreases global brain glucose uptake in humans
  publication-title: J Physiol
– volume: 47
  start-page: 2053
  year: 2015
  end-page: 2061
  ident: bib13
  article-title: The effects of breaking up prolonged sitting time: a review of experimental studies
  publication-title: Med Sci Sports Exerc
– volume: 380
  start-page: 168
  year: 1996
  end-page: 171
  ident: bib39
  article-title: beta-Amyloid-mediated vasoactivity and vascular endothelial damage
  publication-title: Nature
– volume: 22
  start-page: 782
  year: 2014
  end-page: 791
  ident: bib55
  article-title: Executive functions of sedentary elderly may benefit from walking: a systematic review and meta-analysis
  publication-title: Am J Geriatr Psychiatry
– volume: 388
  start-page: 1302
  year: 2016
  end-page: 1310
  ident: bib10
  article-title: Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women
  publication-title: Lancet (London, England)
– volume: 468
  start-page: 232
  year: 2010
  end-page: 241
  ident: bib32
  article-title: Glial and neuronal control of brain blood flow
  publication-title: Nature
– volume: 74
  start-page: 1
  year: 2000
  end-page: 20
  ident: bib25
  article-title: Apoptosis and the nervous system
  publication-title: J Neurochem
– volume: 64
  start-page: 2571
  year: 2015
  end-page: 2580
  ident: bib34
  article-title: Effects of acute and antecedent hypoglycemia on endothelial function and markers of atherothrombotic balance in healthy humans
  publication-title: Diabetes
– volume: 9
  year: 2013
  ident: bib2
  article-title: The worldwide economic impact of dementia 2010
  publication-title: Alzheimers Dement
– volume: 13
  start-page: 12629
  year: 2012
  end-page: 12655
  ident: bib16
  article-title: The role of glucose transporters in brain disease: diabetes and Alzheimer’s disease
  publication-title: Int J Mol Sci
– volume: 6
  start-page: 32044
  year: 2016
  ident: bib46
  article-title: Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: ancillary analysis from randomized clinical trials
  publication-title: Sci Rep
– volume: 51
  start-page: 800
  year: 2017
  end-page: 811
  ident: bib12
  article-title: What is the association between sedentary behaviour and cognitive function? A systematic review
  publication-title: Br J Sports Med
– volume: 184
  start-page: 97
  year: 2012
  end-page: 105
  ident: bib51
  article-title: Regional cerebral blood flow distribution during exercise: influence of oxygen
  publication-title: Respir Physiol Neurobiol
– volume: 11
  start-page: 602
  year: 1958
  ident: bib20
  article-title: Electroencephalographic studies in the syndrome of relative cerebral hypoglycaemia
  publication-title: Electroencephalogr Clin Neurophysiol
– volume: 56
  start-page: 89
  year: 2007
  end-page: 100
  ident: bib31
  article-title: Mechanisms involved in the cerebrovascular dilator effects of N-methyl-D-aspartate in cerebral cortex
  publication-title: Brain Res Rev
– volume: 15
  start-page: 1298
  year: 2009
  end-page: 1306
  ident: bib35
  article-title: Activation of PKCδ and SHP1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
  publication-title: Nat Med
– volume: 6
  start-page: e009630
  year: 2016
  ident: bib52
  article-title: Acute effects of breaking up prolonged sitting on fatigue and cognition: a pilot study
  publication-title: BMJ Open
– volume: 3
  start-page: 186
  year: 2007
  end-page: 191
  ident: bib3
  article-title: Forecasting the global burden of Alzheimer’s disease
  publication-title: Alzheimers Dement
– volume: 109
  start-page: 1518
  year: 2012
  end-page: 1523
  ident: bib24
  article-title: Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
  publication-title: Proc Natl Acad Sci U S A
– volume: 40
  start-page: 223
  year: 1991
  end-page: 226
  ident: bib27
  article-title: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans
  publication-title: Diabetes
– volume: 171
  start-page: 1989
  year: 2007
  end-page: 1999
  ident: bib38
  article-title: Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
  publication-title: Am J Pathol
– volume: 33
  start-page: 2169
  year: 2010
  end-page: 2174
  ident: bib43
  article-title: Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients
  publication-title: Diabetes Care
– volume: 68
  start-page: 51
  year: 2011
  end-page: 57
  ident: bib19
  article-title: Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
  publication-title: Arch Neurol
– volume: 37
  start-page: 540
  year: 2012
  end-page: 542
  ident: bib44
  article-title: Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”
  publication-title: Appl Physiol Nutr Metab
– volume: 91
  start-page: 9352
  year: 1994
  end-page: 9356
  ident: bib29
  article-title: Adaptation in brain glucose uptake following recurrent hypoglycemia
  publication-title: Proc Natl Acad Sci U S A
– volume: 16
  start-page: 114
  year: 2016
  ident: bib47
  article-title: Sitting less and moving more: improved glycemic control for type 2 diabetes prevention and management
  publication-title: Curr Diab Rep
– volume: 82
  start-page: 525
  year: 2005
  end-page: 530
  ident: bib30
  article-title: Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia
  publication-title: J Neurosci Res
– volume: 301
  start-page: 1565
  year: 2009
  end-page: 1572
  ident: bib23
  article-title: Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
  publication-title: JAMA
– volume: 3
  start-page: 75
  year: 2015
  end-page: 89
  ident: bib41
  article-title: Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review
  publication-title: Lancet Diabetes Endocrinol
– volume: 54
  start-page: 162
  year: 2007
  end-page: 180
  ident: bib36
  article-title: Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases
  publication-title: Brain Res Rev
– volume: 60
  start-page: 490
  year: 2017
  end-page: 498
  ident: bib48
  article-title: Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycemic control and insulin sensitivity in type 2 diabetes
  publication-title: Diabetologia
– volume: 14
  start-page: 522
  year: 2014
  ident: bib9
  article-title: Managing sedentary behavior to reduce the risk of diabetes and cardiovascular disease
  publication-title: Curr Diab Rep
– volume: 290
  start-page: 96
  year: 2010
  end-page: 101
  ident: bib40
  article-title: The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer’s disease: a longitudinal SPECT study
  publication-title: J Neurol Sci
– volume: 29
  start-page: 92
  year: 1997
  end-page: 96
  ident: bib26
  article-title: Hierarchy of physiological responses to hypoglycemia: relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus
  publication-title: Horm Metab Res
– volume: 214
  start-page: 456
  year: 1981
  end-page: 457
  ident: bib21
  article-title: Blood-brain glucose transfer: repression in chronic hyperglycemia
  publication-title: Science
– volume: 22
  start-page: 63
  year: 2014
  end-page: 74
  ident: bib54
  article-title: Mental and physical activities delay cognitive decline in older persons with dementia
  publication-title: Am J Geriatr Psychiatry
– volume: 37
  start-page: 540
  year: 2012
  end-page: 542
  article-title: Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”
  publication-title: Appl Physiol Nutr Metab
– volume: 40
  start-page: 223
  year: 1991
  end-page: 226
  article-title: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans
  publication-title: Diabetes
– volume: 29
  start-page: 92
  year: 1997
  end-page: 96
  article-title: Hierarchy of physiological responses to hypoglycemia: relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus
  publication-title: Horm Metab Res
– volume: 162
  start-page: 123
  year: 2015
  article-title: Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults
  publication-title: Ann Intern Med
– volume: 22
  start-page: 782
  year: 2014
  end-page: 791
  article-title: Executive functions of sedentary elderly may benefit from walking: a systematic review and meta‐analysis
  publication-title: Am J Geriatr Psychiatry
– volume: 33
  start-page: 2169
  year: 2010
  end-page: 2174
  article-title: Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients
  publication-title: Diabetes Care
– volume: 309
  start-page: 63
  year: 2013
  end-page: 70
  article-title: Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
  publication-title: JAMA
– volume: 6
  start-page: 32044
  year: 2016
  article-title: Frequent interruptions of sedentary time modulates contraction‐ and insulin‐stimulated glucose uptake pathways in muscle: ancillary analysis from randomized clinical trials
  publication-title: Sci Rep
– volume: 22
  start-page: 63
  year: 2014
  end-page: 74
  article-title: Mental and physical activities delay cognitive decline in older persons with dementia
  publication-title: Am J Geriatr Psychiatry
– volume: 23
  start-page: 163
  year: 2000
  end-page: 170
  article-title: Progressive hypoglycemia's impact on driving simulation performance. Occurrence, awareness and correction
  publication-title: Diabetes Care
– volume: 9
  year: 2013
  article-title: The worldwide economic impact of dementia 2010
  publication-title: Alzheimers Dement
– volume: 77
  start-page: 731
  year: 1997
  end-page: 758
  article-title: Cellular energy utilization and molecular origin of standard metabolic rate in mammals
  publication-title: Physiol Rev
– volume: 43
  start-page: 1334
  year: 2011
  end-page: 1359
  article-title: American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise
  publication-title: Med Sci Sports Exerc
– volume: 9
  year: 2013
  article-title: The global prevalence of dementia: a systematic review and metaanalysis
  publication-title: Alzheimers Dement
– volume: 214
  start-page: 456
  year: 1981
  end-page: 457
  article-title: Blood‐brain glucose transfer: repression in chronic hyperglycemia
  publication-title: Science
– volume: 10
  start-page: 969
  year: 2011
  end-page: 977
  article-title: Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open‐label substudy
  publication-title: Lancet Neurol
– volume: 60
  start-page: 390
  year: 2017
  end-page: 394
  article-title: Adding exercise or subtracting sitting time for glycemic control: where do we stand?
  publication-title: Diabetologia
– volume: 568
  start-page: 323
  year: 2005
  end-page: 332
  article-title: High intensity exercise decreases global brain glucose uptake in humans
  publication-title: J Physiol
– volume: 50
  start-page: 1443
  year: 2016
  article-title: Aerobic exercise ameliorates cognitive function in older adults with mild cognitive impairment: a systematic review and meta‐analysis of randomised controlled trials
  publication-title: Br J Sports Med
– volume: 54
  start-page: 162
  year: 2007
  end-page: 180
  article-title: Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion‐related neurodegenerative diseases
  publication-title: Brain Res Rev
– volume: 380
  start-page: 168
  year: 1996
  end-page: 171
  article-title: beta‐Amyloid‐mediated vasoactivity and vascular endothelial damage
  publication-title: Nature
– volume: 3
  start-page: 186
  year: 2007
  end-page: 191
  article-title: Forecasting the global burden of Alzheimer's disease
  publication-title: Alzheimers Dement
– volume: 62
  start-page: 1125
  year: 2014
  end-page: 1141
  article-title: Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
  publication-title: Glia
– volume: 171
  start-page: 1989
  year: 2007
  end-page: 1999
  article-title: Lipoprotein receptor‐related protein‐1 mediates amyloid‐beta‐mediated cell death of cerebrovascular cells
  publication-title: Am J Pathol
– volume: 109
  start-page: 1518
  year: 2012
  end-page: 1523
  article-title: Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
  publication-title: Proc Natl Acad Sci U S A
– volume: 74
  start-page: 1
  year: 2000
  end-page: 20
  article-title: Apoptosis and the nervous system
  publication-title: J Neurochem
– volume: 184
  start-page: 97
  year: 2012
  end-page: 105
  article-title: Regional cerebral blood flow distribution during exercise: influence of oxygen
  publication-title: Respir Physiol Neurobiol
– volume: 13
  start-page: 12629
  year: 2012
  end-page: 12655
  article-title: The role of glucose transporters in brain disease: diabetes and Alzheimer's disease
  publication-title: Int J Mol Sci
– volume: 290
  start-page: 96
  year: 2010
  end-page: 101
  article-title: The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study
  publication-title: J Neurol Sci
– volume: 468
  start-page: 232
  year: 2010
  end-page: 241
  article-title: Glial and neuronal control of brain blood flow
  publication-title: Nature
– volume: 15
  start-page: 1298
  year: 2009
  end-page: 1306
  article-title: Activation of PKCδ and SHP1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
  publication-title: Nat Med
– volume: 56
  start-page: 89
  year: 2007
  end-page: 100
  article-title: Mechanisms involved in the cerebrovascular dilator effects of N‐methyl‐D‐aspartate in cerebral cortex
  publication-title: Brain Res Rev
– volume: 20
  start-page: 489
  year: 2016
  end-page: 493
  article-title: Acute effects on cognitive performance following bouts of standing and light‐intensity physical activity in a simulated workplace environment
  publication-title: J Sci Med Sport
– volume: 89
  start-page: 37
  year: 2016
  end-page: 43
  article-title: Prevalence and trends in physical activity among older adults in the United States: a comparison across three national surveys
  publication-title: Prev Med (Baltim)
– volume: 47
  start-page: 2053
  year: 2015
  end-page: 2061
  article-title: The effects of breaking up prolonged sitting time: a review of experimental studies
  publication-title: Med Sci Sports Exerc
– volume: 60
  start-page: 490
  year: 2017
  end-page: 498
  article-title: Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycemic control and insulin sensitivity in type 2 diabetes
  publication-title: Diabetologia
– volume: 388
  start-page: 1302
  year: 2016
  end-page: 1310
  article-title: Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta‐analysis of data from more than 1 million men and women
  publication-title: Lancet (London, England)
– volume: 64
  start-page: 2571
  year: 2015
  end-page: 2580
  article-title: Effects of acute and antecedent hypoglycemia on endothelial function and markers of atherothrombotic balance in healthy humans
  publication-title: Diabetes
– volume: 6
  start-page: 187
  year: 2015
  article-title: Biochemical markers of physical exercise on mild cognitive impairment and dementia: systematic review and perspectives
  publication-title: Front Neurol
– volume: 14
  start-page: 522
  year: 2014
  article-title: Managing sedentary behavior to reduce the risk of diabetes and cardiovascular disease
  publication-title: Curr Diab Rep
– volume: 369
  start-page: 540
  year: 2013
  end-page: 548
  article-title: Glucose levels and risk of dementia
  publication-title: N Engl J Med
– volume: 3
  start-page: 75
  year: 2015
  end-page: 89
  article-title: Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review
  publication-title: Lancet Diabetes Endocrinol
– volume: 82
  start-page: 525
  year: 2005
  end-page: 530
  article-title: Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia
  publication-title: J Neurosci Res
– volume: 51
  start-page: 800
  year: 2017
  end-page: 811
  article-title: What is the association between sedentary behaviour and cognitive function? A systematic review
  publication-title: Br J Sports Med
– volume: 91
  start-page: 9352
  year: 1994
  end-page: 9356
  article-title: Adaptation in brain glucose uptake following recurrent hypoglycemia
  publication-title: Proc Natl Acad Sci U S A
– volume: 380
  start-page: 247
  year: 2012
  end-page: 257
  article-title: Global physical activity levels: surveillance progress, pitfalls, and prospects
  publication-title: Lancet
– volume: 11
  start-page: 602
  year: 1958
  article-title: Electroencephalographic studies in the syndrome of relative cerebral hypoglycaemia
  publication-title: Electroencephalogr Clin Neurophysiol
– volume: 30
  start-page: 162
  year: 2010
  end-page: 176
  article-title: Trafficking of glucose, lactate, and amyloid‐β from the inferior colliculus through perivascular routes
  publication-title: J Cereb Blood Flow Metab
– volume: 32
  start-page: 590
  year: 2011
  end-page: 597
  article-title: Sedentary time and cardio‐metabolic biomarkers in US adults: NHANES 200306
  publication-title: Eur Heart J
– volume: 42
  start-page: 484
  year: 2012
  end-page: 491
  article-title: Diabetes as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies
  publication-title: Intern Med J
– volume: 16
  start-page: 114
  year: 2016
  article-title: Sitting less and moving more: improved glycemic control for type 2 diabetes prevention and management
  publication-title: Curr Diab Rep
– volume: 6
  year: 2016
  article-title: Acute effects of breaking up prolonged sitting on fatigue and cognition: a pilot study
  publication-title: BMJ Open
– volume: 369
  start-page: 362
  year: 2013
  end-page: 372
  article-title: Mechanisms of hypoglycemia‐associated autonomic failure in diabetes
  publication-title: N Engl J Med
– volume: 301
  start-page: 1565
  year: 2009
  end-page: 1572
  article-title: Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
  publication-title: JAMA
– volume: 68
  start-page: 51
  year: 2011
  end-page: 57
  article-title: Insulin resistance and Alzheimer‐like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
  publication-title: Arch Neurol
– ident: e_1_2_14_48_1
  doi: 10.1007/s11892-016-0797-4
– ident: e_1_2_14_17_1
  doi: 10.3390/ijms131012629
– ident: e_1_2_14_52_1
  doi: 10.1016/j.resp.2012.07.014
– ident: e_1_2_14_53_1
  doi: 10.1136/bmjopen-2015-009630
– ident: e_1_2_14_47_1
  doi: 10.1038/srep32044
– ident: e_1_2_14_15_1
  doi: 10.1152/physrev.1997.77.3.731
– ident: e_1_2_14_46_1
  doi: 10.1093/eurheartj/ehq451
– ident: e_1_2_14_37_1
  doi: 10.1016/j.brainresrev.2007.01.003
– ident: e_1_2_14_19_1
  doi: 10.1056/NEJMoa1215740
– ident: e_1_2_14_55_1
  doi: 10.1016/j.jagp.2013.01.060
– ident: e_1_2_14_5_1
  doi: 10.3389/fneur.2015.00187
– ident: e_1_2_14_13_1
  doi: 10.1136/bjsports-2015-095551
– ident: e_1_2_14_16_1
  doi: 10.1002/glia.22667
– ident: e_1_2_14_7_1
  doi: 10.1249/MSS.0b013e318213fefb
– ident: e_1_2_14_33_1
  doi: 10.1038/nature09613
– ident: e_1_2_14_36_1
  doi: 10.1038/nm.2052
– ident: e_1_2_14_23_1
  doi: 10.2337/diacare.23.2.163
– ident: e_1_2_14_22_1
  doi: 10.1126/science.7027439
– ident: e_1_2_14_27_1
  doi: 10.1055/s-2007-978997
– ident: e_1_2_14_34_1
  doi: 10.1001/jama.2012.116975
– ident: e_1_2_14_10_1
  doi: 10.1007/s11892-014-0522-0
– ident: e_1_2_14_18_1
  doi: 10.1111/j.1445-5994.2012.02758.x
– volume: 9
  year: 2013
  ident: e_1_2_14_2_1
  article-title: The global prevalence of dementia: a systematic review and metaanalysis
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2012.11.007
– ident: e_1_2_14_20_1
  doi: 10.1001/archneurol.2010.225
– ident: e_1_2_14_32_1
  doi: 10.1016/j.brainresrev.2007.05.011
– ident: e_1_2_14_41_1
  doi: 10.1016/j.jns.2009.10.022
– volume: 11
  start-page: 602
  year: 1958
  ident: e_1_2_14_21_1
  article-title: Electroencephalographic studies in the syndrome of relative cerebral hypoglycaemia
  publication-title: Electroencephalogr Clin Neurophysiol
– ident: e_1_2_14_45_1
  doi: 10.1139/h2012-024
– volume: 369
  start-page: 362
  year: 2013
  ident: e_1_2_14_29_1
  article-title: Mechanisms of hypoglycemia‐associated autonomic failure in diabetes
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1215228
– ident: e_1_2_14_49_1
  doi: 10.1007/s00125-016-4161-7
– ident: e_1_2_14_56_1
  doi: 10.1016/j.jagp.2012.12.026
– ident: e_1_2_14_26_1
  doi: 10.1046/j.1471-4159.2000.0740001.x
– ident: e_1_2_14_40_1
  doi: 10.1038/380168a0
– ident: e_1_2_14_38_1
  doi: 10.1038/jcbfm.2009.206
– ident: e_1_2_14_11_1
  doi: 10.1016/S0140-6736(16)30370-1
– ident: e_1_2_14_35_1
  doi: 10.2337/db14-1729
– ident: e_1_2_14_3_1
  doi: 10.1016/j.jalz.2012.11.006
– ident: e_1_2_14_6_1
  doi: 10.1136/bjsports-2015-095699
– ident: e_1_2_14_43_1
  doi: 10.1016/S1474-4422(11)70188-0
– ident: e_1_2_14_44_1
  doi: 10.2337/dc10-0389
– ident: e_1_2_14_12_1
  doi: 10.7326/M14-1651
– ident: e_1_2_14_25_1
  doi: 10.1073/pnas.1108225109
– ident: e_1_2_14_50_1
  doi: 10.1007/s00125-016-4180-4
– ident: e_1_2_14_28_1
  doi: 10.2337/diab.40.2.223
– volume: 20
  start-page: 489
  year: 2016
  ident: e_1_2_14_54_1
  article-title: Acute effects on cognitive performance following bouts of standing and light‐intensity physical activity in a simulated workplace environment
  publication-title: J Sci Med Sport
  doi: 10.1016/j.jsams.2016.09.015
– ident: e_1_2_14_39_1
  doi: 10.2353/ajpath.2007.070050
– ident: e_1_2_14_31_1
  doi: 10.1002/jnr.20654
– ident: e_1_2_14_9_1
  doi: 10.1016/j.ypmed.2016.05.009
– ident: e_1_2_14_14_1
  doi: 10.1249/MSS.0000000000000654
– ident: e_1_2_14_42_1
  doi: 10.1016/S2213-8587(14)70148-2
– ident: e_1_2_14_8_1
  doi: 10.1016/S0140-6736(12)60646-1
– ident: e_1_2_14_24_1
  doi: 10.1001/jama.2009.460
– ident: e_1_2_14_4_1
  doi: 10.1016/j.jalz.2007.04.381
– ident: e_1_2_14_51_1
  doi: 10.1113/jphysiol.2005.091355
– ident: e_1_2_14_30_1
  doi: 10.1073/pnas.91.20.9352
SSID ssj0001528935
Score 2.4247642
SecondaryResourceType review_article
Snippet Abstract Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the...
Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 291
SubjectTerms Alzheimer's disease
Apoptosis
Brain research
Breaks in sedentary time
Chronic illnesses
Cognitive function
Dementia
Diabetes
Energy
Exercise
Glucose
Glucose metabolism
Hyperglycemia
Hypoglycemia
Insulin resistance
Investigations
Light-intensity activity
Metabolism
Neurology
Neuropathology
Older people
Other
Physical activity
Public health
Sedentary behavior
Sitting
SummonAdditionalLinks – databaseName: Wiley-Blackwell Open Access Titles
  dbid: 24P
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fS9xAEF7EvvSlVGrbVC1T8K2kZDeb5IIPIlZRQSn1Cr4t-yvtieTE3CH97zuzm0StVAq-HMdt9rI_Zna_Tb75hrFtZ2WVV46nrtZ1Kq3NUu2NS0XDKyszrBPkmk7PyqMf8uSiuFhhX4dYmKgPMT5wI88I6zU5uDbdvfPm5ZfFjZ0ROasKYqUUxPWCYmxJQV_Ib3dPWgo8VIRMmwLRBrp_XvXRM5Ho9fff_GuHeoxAHxMp7wPcsEMdvmavemgJe9EW1tiKb9-w23NPobjYTRgi8kF3oIE45RCz7QACVxh5ROA8hUv6XdjDArvsYN4CwkSYDflMYN7Az6vflnj10HPdsRQMpZuAGFm5zqaHB9P9o7RPtpBaPMPw1ODW7hsrrCuFcdLmRuNI4YLgjCt1aUo3sbppimZSaNHYWgatN016-9Jzn79lq-289e8Z4BGEO--FyYyVvG4Mr3ReytpIg5aRiYTxYXyV7YXIKR_GlRoYZ5eK5kTRnKhMEu0uYZ_HOtdRhuPJq6th2tQQYIpLou96_-wUV51QmToniyCD4CTbLwpsWzHW7CFIhBYKDfDJO24O1qHGm-BpTfCc5JMS9mksRveldzK69fMlNqQmhTaBjUjYu2hMYwdJib_K8wK788DMxgtIGvxhSTv7FSTCEaZzyScJ2wkG-R9jpqbf98UJfhzTj7S08w_Pqr3BXtL3yMfbZKuLm6XfQgC3MB-Df_4BW3Y-6A
  priority: 102
  providerName: Wiley-Blackwell
Title Sedentary behavior as a risk factor for cognitive decline: A focus on the influence of glycemic control in brain health
URI https://www.clinicalkey.es/playcontent/1-s2.0-S2352873717300252
https://dx.doi.org/10.1016/j.trci.2017.04.001
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.trci.2017.04.001
https://www.ncbi.nlm.nih.gov/pubmed/29067335
https://www.proquest.com/docview/2552137100
https://www.proquest.com/docview/1955632287
https://pubmed.ncbi.nlm.nih.gov/PMC5651418
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1La9wwEBZNcimU0nfdposKvRVTS5atNT2ENCSkgYaQbGFvQi-nW4Kdrncp-fedsWSnIWXpxQdLwnqMpE_yN98Q8sFZIXPpWOoqXaXC2izV3riU10xakUGZXq7p22l5_F2czIt5vHDrIq1yWBP7hdq1Fu_IPwH05SxHLZq9618pRo3Cv6sxhMYW2UHpMqR0ybm8vWMp4DjRx9jkgDNg4ucy-s0EitdqaRfI7pK92mmMC_OPvek-9rxPofwb2vZ709ET8jiCSrofrOApeeCbZ-RRuJGjwdHoOfl94dEpVy9v6OCbT3VHNUV2OQ1xdyhAWDoyiqjz6Djp9-g-JNh1R9uGAmCkiyGyCW1renl1Y5FhTyPrHVKpwcATNPhYviCzo8PZwXEawy6kFk4zLDWwyfvacutKbpywudHQc7A0OONKXZrSTa2u66KeFprXthK96ptG5X3hmc9fku2mbfxrQuEwwpz33GTGClbVhkmdl6IywoCNZDwhbOhvZaMkOUbGuFID9-ynwjFSOEYqE0jAS8jHscx1EOTYmFsOw6gGV1NYHH0XZ2qnmOq4ytQFWggaCEMBf15A3YqxZAQjAWQo2Gs2fnF3sBY1fuTWeBPyfkyGiYx_Z3Tj2zVUpEKtNg6VSMirYFxjA1GTX-Z5Ac25Y3ZjBhQJv5vSLH70YuEA2Jlg04R87g30P_pMzc4P-Ak8vuJLXOTZm82NekseYtZAvdsl26vl2r8DrLYyE7LFxdmkn5YTsvPl8PTsfNLfe_wBgJU_pg
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZG9wASQtwpDDASPKGI2HGSRghNY2xqd6nQVqS9Wb6FdZqS0bSa-qP4j5wTJxnTUMXLXvIQx4kdnxx_dr5zPkLeWyPSKLUssJnKAmFMGCinbcBzlhoRQp06XdPhOBn-EHsn8cka-d3GwiCtsvWJtaO2pcE98k8AfTmLMBfN5sWvAFWj8O9qK6HhzWLfLS9hyVZ9GX2D8f3A-e7OZHsYNKoCgQGwzgINc5jLDTc24doKE2k1SNHyrbaJSnRiB0bleZwPYsVzk4k6qZnCxPLCMRfBbe-QdRHBSqZH1r_ujL8fXW3qxLB-qUU9OQAb8DRR2gTqeE7ZfGamSCdL6_SqjRDNPybDm2D3JmfzbyxdT4a7D8mDBsXSLW92j8iaKx6T-34LkPrIpifk8thhFLCaLWmbDICqiiqKdHbqhX4oYGbaUZiodRip6TbpFhSYRUXLggJCpdNWSoWWOf15vjRI6acNzR5KqUalC-qDOp-SyW2MyDPSK8rCvSAUVj_MOsd1qI1gWa5ZqqJEZFpoMMqQ9wlr37c0TQ50lOI4ly3Z7UziGEkcIxkKZPz1yceuzoXPALLy6rQdRtnGtoI3dlXjGirJZMVlKI_RQtBAGCoG8BjaFnc1G_TjUY2EyW3lEzdaa5HdQ66-lj551xWD58DfQapw5QIakmFyOA6N6JPn3ri6DqIIQBpFMXTnmtl1F2BW8uslxfS0zk4OKwQm2KBPPtcG-h_vTE6OtvkeHEZ4EmcV9nJ1p96Su8PJ4YE8GI33X5F7WM3z_jZIbz5buNcAFOf6TfN5UiJv2SH8AVEYer8
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLXGkBASQnxTGGAkeELRYseJGyE0TRvVusGEWJH6ZvkrUDQlo2k19afx77g3TjKmoYqXvfQhjhs7vr4-ds69h5A3zgqZSMcil-s8EtbGkfbGRbxg0ooY6jTpmj4fZwffxOE0nW6Q310sDNIqO5_YOGpXWTwj3wboy1mCuWi2i5YW8WV_tHP2K0IFKfzS2slpBBM58qtz2L7VH8b7MNZvOR99nOwdRK3CQGQBuLPIwHrmC8uty7hxwiZGDyXOAmdcpjOTuaHVRZEWw1TzwuaiSXCmMcm88Mwn8Lc3yE2ZpAynmJzKi-OdFHYyjbwnB4gDPieRbchOYJct5naGxDLZJFptJWn-sSxehb1X2Zt_o-pmWRzdI3dbPEt3gwHeJxu-fEDuhMNAGmKcHpLzE4_xwHq-ol1aAKprqikS22mQ_KGAnmlPZqLOY8ym36G7UGCXNa1KCliVzjpRFVoV9PvpyiK5n7aEeyilBjUvaAjvfEQm1zEej8lmWZX-KaGwD2LOe25iYwXLC8OkTjKRG2HAPGM-IKx738q22dBRlONUdbS3nwrHSOEYqVgg929A3vV1zkIukLV3y24YVRflCn7Z162TqBVTNVexOkELQQNhqB3AU2hb2tdscVDANwqWubVP3OqsRfUPuZg3A_K6LwYfgh-GdOmrJTQkxzRxHBoxIE-CcfUdRDkAmSQpdOeS2fU3YH7yyyXl7EeTpxz2Ckyw4YC8bwz0P96Zmnzd44fwM8aLuL6wZ-s79YrcAjegPo2Pj56T21grEAC3yOZivvQvADEuzMtmblKirtkX_AGweH2P
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sedentary+behavior+as+a+risk+factor+for+cognitive+decline%3F+A+focus+on+the+influence+of+glycemic+control+in+brain+health&rft.jtitle=Alzheimer%27s+%26+dementia+%3A+translational+research+%26+clinical+interventions&rft.au=Wheeler%2C+Michael+J.&rft.au=Dempsey%2C+Paddy+C.&rft.au=Grace%2C+Megan+S.&rft.au=Ellis%2C+Kathryn+A.&rft.date=2017-09-01&rft.pub=Elsevier&rft.eissn=2352-8737&rft.volume=3&rft.issue=3&rft.spage=291&rft.epage=300&rft_id=info:doi/10.1016%2Fj.trci.2017.04.001&rft_id=info%3Apmid%2F29067335&rft.externalDocID=PMC5651418
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-8737&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-8737&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-8737&client=summon