Marked gender differences in progression of mild cognitive impairment over 8 years

Abstract Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimagin...

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Published inAlzheimer's & dementia : translational research & clinical interventions Vol. 1; no. 2; pp. 103 - 110
Main Authors Lin, Katherine A, Choudhury, Kingshuk Roy, Rathakrishnan, Bharath G, Marks, David M, Petrella, Jeffrey R, Doraiswamy, P. Murali
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2015
John Wiley & Sons, Inc
Elsevier
Subjects
Activities of daily living
Age
Alzheimer's disease
Apolipoprotein ε4
Apolipoproteins
Beta-amyloid
Cognition & reasoning
Cognitive ability
Dementia
Education
Females
Gender differences
Hypotheses
Medical imaging
Memory
Neurology
Normal distribution
Older people
Other
Procedure manuals
Secondary prevention
United States > US
Secondary prevention
Apolipoprotein ε4
Gender differences
Activities of daily living
Beta-amyloid
prevalence
secondary prevention
gender differences
disease modification
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Abstract Abstract Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimaging Initiative-1, followed for up to 8 years (mean, 4.1 ± 2.5 years) using mixed-effects models incorporating all follow-ups (mean, 8 ± 4 visits). Results Women progressed at faster rates than men on the Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog; P  = .001) and clinical dementia rating-sum of boxes (CDR-SB; P  = .003). Quadratic fit for change over time was significant for both ADAS-Cog ( P  = .001) and CDR-SB ( P  = .004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in apolipoprotein E ( APOE ) ε4 carriers. Discussion Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted. Trial Registration ADNI ClinicalTrials.gov identifier: NCT00106899.
AbstractList This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. We examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimaging Initiative-1, followed for up to 8 years (mean, 4.1 ± 2.5 years) using mixed-effects models incorporating all follow-ups (mean, 8 ± 4 visits). Women progressed at faster rates than men on the Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog; P = .001) and clinical dementia rating-sum of boxes (CDR-SB; P = .003). Quadratic fit for change over time was significant for both ADAS-Cog (P = .001) and CDR-SB (P = .004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in apolipoprotein E (APOE) ε4 carriers. Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted. ADNI ClinicalTrials.gov identifier: NCT00106899.
Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimaging Initiative‐1, followed for up to 8 years (mean, 4.1 ± 2.5 years) using mixed‐effects models incorporating all follow‐ups (mean, 8 ± 4 visits). Results Women progressed at faster rates than men on the Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog; P = .001) and clinical dementia rating‐sum of boxes (CDR‐SB; P = .003). Quadratic fit for change over time was significant for both ADAS‐Cog (P = .001) and CDR‐SB (P = .004), and the additional acceleration in women was 100% for ADAS‐Cog and 143% for CDR‐SB. The variability of change was greater in women. The gender effect was greater in apolipoprotein E (APOE) ε4 carriers. Discussion Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted. Trial Registration ADNI ClinicalTrials.gov identifier: NCT00106899.
INTRODUCTIONThis study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men.METHODSWe examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean 4.1±2.5 years) using mixed effects models incorporating all follow ups (mean 8±4 visits).RESULTSWomen progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003). Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in ApoE4 carriers.DISCUSSIONWomen with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.
IntroductionThis study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men.MethodsWe examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimaging Initiative‐1, followed for up to 8 years (mean, 4.1 ± 2.5 years) using mixed‐effects models incorporating all follow‐ups (mean, 8 ± 4 visits).ResultsWomen progressed at faster rates than men on the Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog; P = .001) and clinical dementia rating‐sum of boxes (CDR‐SB; P = .003). Quadratic fit for change over time was significant for both ADAS‐Cog (P = .001) and CDR‐SB (P = .004), and the additional acceleration in women was 100% for ADAS‐Cog and 143% for CDR‐SB. The variability of change was greater in women. The gender effect was greater in apolipoprotein E (APOE) ε4 carriers.DiscussionWomen with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.Trial RegistrationADNI ClinicalTrials.gov identifier: NCT00106899.
Abstract Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine longitudinal rates of change from baseline in 398 MCI subjects (141 females and 257 males) in the Alzheimer's Disease Neuroimaging Initiative-1, followed for up to 8 years (mean, 4.1 ± 2.5 years) using mixed-effects models incorporating all follow-ups (mean, 8 ± 4 visits). Results Women progressed at faster rates than men on the Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog; P  = .001) and clinical dementia rating-sum of boxes (CDR-SB; P  = .003). Quadratic fit for change over time was significant for both ADAS-Cog ( P  = .001) and CDR-SB ( P  = .004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in apolipoprotein E ( APOE ) ε4 carriers. Discussion Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted. Trial Registration ADNI ClinicalTrials.gov identifier: NCT00106899.
This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean 4.1±2.5 years) using mixed effects models incorporating all follow ups (mean 8±4 visits). Women progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003). Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in ApoE4 carriers. Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.
Author Rathakrishnan, Bharath G.
Lin, Katherine A.
Petrella, Jeffrey R.
Choudhury, Kingshuk Roy
Marks, David M.
Doraiswamy, P. Murali
AuthorAffiliation c Department of Radiology, Duke University Medical Center, Durham, NC, USA
a Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
b Duke Institute for Brain Sciences, Duke University, Durham, NC, USA
AuthorAffiliation_xml – name: a Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
– name: c Department of Radiology, Duke University Medical Center, Durham, NC, USA
– name: b Duke Institute for Brain Sciences, Duke University, Durham, NC, USA
Author_xml – sequence: 1
  fullname: Lin, Katherine A
– sequence: 2
  fullname: Choudhury, Kingshuk Roy
– sequence: 3
  fullname: Rathakrishnan, Bharath G
– sequence: 4
  fullname: Marks, David M
– sequence: 5
  fullname: Petrella, Jeffrey R
– sequence: 6
  fullname: Doraiswamy, P. Murali
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26451386$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords Secondary prevention
Apolipoprotein ε4
Gender differences
Activities of daily living
Beta-amyloid
prevalence
secondary prevention
gender differences
disease modification
Language English
License http://creativecommons.org/licenses/by-nc-nd/4.0
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Snippet Abstract Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We...
This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. We examine longitudinal rates of...
Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine...
IntroductionThis study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men.MethodsWe examine...
INTRODUCTIONThis study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men.METHODSWe examine...
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StartPage 103
SubjectTerms Activities of daily living
Age
Alzheimer's disease
Apolipoprotein ε4
Apolipoproteins
Beta-amyloid
Cognition & reasoning
Cognitive ability
Dementia
Education
Females
Gender differences
Hypotheses
Medical imaging
Memory
Neurology
Normal distribution
Older people
Other
Procedure manuals
Secondary prevention
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Title Marked gender differences in progression of mild cognitive impairment over 8 years
URI https://www.clinicalkey.es/playcontent/1-s2.0-S2352873715000190
https://dx.doi.org/10.1016/j.trci.2015.07.001
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