干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙型肝炎疗效观察
R512.6+2; 目的 为探讨干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙型肝炎的疗效.方法 选择120例(HBeAg阳性)慢性乙型肝炎患者,随机分为治疗组和对照组:治疗组56例应用干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗;对照组64例采用干扰素α、泛昔洛韦治疗,治疗前后分别检测肝功、乙肝五项和HBVDNA,并在第16、20、24周分别检测HBVDNA水平以观察其变化.结果 治疗结束时,治疗组和对照组ALT复常率为92.9%和87.5%(P＞0.05)差异无著意义;HBeAg阴转率为76.7%和56.3.%(P＜0.05);治疗16、20和24周BHVDNA水平较对照组下降(P＜0.0...
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| Published in | 临床肝胆病杂志 Vol. 26; no. 3; pp. 321 - 322 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
山东省枣矿集团公司滕南医院传染科,山东,微山,277606
2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
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| Abstract | R512.6+2; 目的 为探讨干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙型肝炎的疗效.方法 选择120例(HBeAg阳性)慢性乙型肝炎患者,随机分为治疗组和对照组:治疗组56例应用干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗;对照组64例采用干扰素α、泛昔洛韦治疗,治疗前后分别检测肝功、乙肝五项和HBVDNA,并在第16、20、24周分别检测HBVDNA水平以观察其变化.结果 治疗结束时,治疗组和对照组ALT复常率为92.9%和87.5%(P＞0.05)差异无著意义;HBeAg阴转率为76.7%和56.3.%(P＜0.05);治疗16、20和24周BHVDNA水平较对照组下降(P＜0.01),BHVDNA阴转率89.3%和59.4%(P＜0.01);两组间HBeAg和HBVDNA阴转率有显著差异.结论 干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙肝疗效更佳. |
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| AbstractList | R512.6+2; 目的 为探讨干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙型肝炎的疗效.方法 选择120例(HBeAg阳性)慢性乙型肝炎患者,随机分为治疗组和对照组:治疗组56例应用干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗;对照组64例采用干扰素α、泛昔洛韦治疗,治疗前后分别检测肝功、乙肝五项和HBVDNA,并在第16、20、24周分别检测HBVDNA水平以观察其变化.结果 治疗结束时,治疗组和对照组ALT复常率为92.9%和87.5%(P＞0.05)差异无著意义;HBeAg阴转率为76.7%和56.3.%(P＜0.05);治疗16、20和24周BHVDNA水平较对照组下降(P＜0.01),BHVDNA阴转率89.3%和59.4%(P＜0.01);两组间HBeAg和HBVDNA阴转率有显著差异.结论 干扰素α、泛昔洛韦和薄芝糖肽注射液联合治疗慢性乙肝疗效更佳. |
| Author | 刘景妨 胡文杰 崔洪岭 封飞 |
| AuthorAffiliation | 山东省枣矿集团公司滕南医院传染科,山东,微山,277606 |
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| Keywords | 干扰素α 肝炎,乙型,慢性 薄芝糖肽注射液 泛昔洛韦 |
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