Experimental infection of pigs with a classical swine fever virus isolated in Japan for the first time in 26 years

• Published in: Journal of Veterinary Medical Science Vol. 81; no. 9; pp. 1277 - 1284
• Main Authors: MASUJIN, Kentaro, FUKAI, Katsuhiko, YAMADA, Manabu, MORIOKA, Kazuki, KAMEYAMA, Ken-ichiro, KOKUHO, Takehiro, NISHI, Tatsuya
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2019; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Antibodies, Viral; Cell Line; Classical Swine Fever - pathology; Classical Swine Fever - transmission; Classical Swine Fever - virology; classical swine fever virus; Classical Swine Fever Virus - genetics; Classical Swine Fever Virus - immunology; Classical Swine Fever Virus - pathogenicity; Experimental infection; Fever; Genotype; Hog cholera; Hogs; Hyperthermia; Infarction; Infections; Inoculation; Japan; Outbreaks; Reverse Transcriptase Polymerase Chain Reaction - veterinary; RNA, Viral - analysis; RNA, Viral - blood; Spleen; Spleen - pathology; Sus scrofa; Swine; Virology; Virulence - genetics; Japan; classical swine fever virus; Japan; experimental infection

Following an outbreak of classical swine fever (CSF) in Japan, 2018, CSFV JPN/1/2018 was isolated from an infected pig sample. In this study, we carried out a comparative experimental infection in pigs using this strain and the highly virulent ALD strain and compared outcomes, including clinical man...