Robustness and evolvability of the human signaling network

• Published in: PLoS computational biology Vol. 10; no. 7; p. e1003763
• Main Authors: Kim, Junil, Vandamme, Drieke, Kim, Jeong-Rae, Munoz, Amaya Garcia, Kolch, Walter, Cho, Kwang-Hyun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2014; Public Library of Science (PLoS)
• Subjects: Algorithms; Behavior; Biology and Life Sciences; Cellular signal transduction; Decomposition; Drug Discovery; Evolution, Molecular; FDA approval; Genes; Humans; Models, Biological; Physiological aspects; Signal transduction; Signal Transduction - genetics; Signal Transduction - physiology; Simulation; Technological planning; Telephone number portability; Values; South Korea; Ireland

Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolvability and robustness of the human signaling netw...