Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder

• Published in: Psychiatry research. Neuroimaging Vol. 174; no. 3; pp. 195 - 201
• Main Authors: Almeida, Jorge R.C., Mechelli, Andrea, Hassel, Stefanie, Versace, Amelia, Kupfer, David J., Phillips, Mary L.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.12.2009; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Bayes Theorem; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - pathology; Bipolar Disorder - physiopathology; Bipolar disorders; Brain Mapping; Case-Control Studies; Dynamic causal modeling; Effective connectivity; Emotion regulation; Emotions - physiology; Female; fMRI; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Models, Statistical; Mood disorders; Neural Pathways; Neuroimaging; Neuropsychological Tests; Nonlinear Dynamics; Oxygen; Parahippocampal Gyrus - blood supply; Parahippocampal Gyrus - physiopathology; Prefrontal Cortex - blood supply; Prefrontal Cortex - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiology; Young Adult; Neuroimaging; fMRI; Bipolar disorder; Dynamic causal modeling; Emotion regulation; Effective connectivity; Mood disorder; Human; Affect affectivity; Central nervous system; ParahIppocampal cortex; Labelling; Emotion emotionality; Prefrontal cortex; Nuclear magnetic resonance imaging; Encephalon; Medical imagery; Self regulation; Causality; Functional imaging

Emotional liability and mood dysregulation characterize bipolar disorder (BD), yet no study has examined effective connectivity between parahippocampal gyrus and prefrontal cortical regions in ventromedial and dorsal/lateral neural systems subserving mood regulation in BD. Participants comprised 46...