An Analysis of a Compact Label-Free Guiding-Wave Biosensor Based on a Semiconductor-Clad Dielectric Strip Waveguide

In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagatio...

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Published inSensors (Basel, Switzerland) Vol. 20; no. 12; p. 3368
Main Author Angulo Barrios, Carlos
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.06.2020
MDPI
Subjects
Amorphous materials
Aqueous solutions
Beams (radiation)
Biofilms
Biosensing Techniques
Biosensors
Boundary conditions
CMOS
Computer simulation
integrated optics
Letter
optical biosensor
Optical measuring instruments
Optics and Photonics
photonic modeling
Propagation
Semiconductors
Sensors
Silicon oxynitride
Simulation
Strip
waveguide
Waveguides
optical biosensor
integrated optics
photonic modeling
waveguide
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Abstract In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.
AbstractList In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.
In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.
In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.
In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible materials such as amorphous-Si and silicon oxynitride. The optical sensor performance has been modeled by a three-dimensional beam propagation method. The simulations indicate that a 20-μm-long device can exhibit a surface limit of detection of 3 ng/cm 2 for avidin molecules in aqueous solution. The sensor performance compares well to those displayed by other photonic biosensors with much larger footprints. The fabrication tolerances have been also studied in order to analyze the feasibility of the practical implementation of the biosensor.
Author Angulo Barrios, Carlos
AuthorAffiliation 1 Institute for Optoelectronic Systems and Microtechnology (ISOM), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain; carlos.angulo.barrios@upm.es
2 Department of Photonics and Bioengineering (TFB), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
AuthorAffiliation_xml – name: 1 Institute for Optoelectronic Systems and Microtechnology (ISOM), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain; carlos.angulo.barrios@upm.es
– name: 2 Department of Photonics and Bioengineering (TFB), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
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  organization: Department of Photonics and Bioengineering (TFB), ETSI Telecomunicación, Universidad Politécnica de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32545866$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_3390_s22030903
crossref_primary_10_1016_j_aej_2022_12_040
crossref_primary_10_1109_JLT_2021_3073805
crossref_primary_10_3390_s20164444
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Issue 12
Keywords optical biosensor
integrated optics
photonic modeling
waveguide
Language English
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SSID ssj0023338
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Snippet In this paper, a compact, integrated, semiconductor-clad strip waveguide label-free biosensor is proposed and analyzed. The device is based on CMOS-compatible...
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StartPage 3368
SubjectTerms Amorphous materials
Aqueous solutions
Beams (radiation)
Biofilms
Biosensing Techniques
Biosensors
Boundary conditions
CMOS
Computer simulation
integrated optics
Letter
optical biosensor
Optical measuring instruments
Optics and Photonics
photonic modeling
Propagation
Semiconductors
Sensors
Silicon oxynitride
Simulation
Strip
waveguide
Waveguides
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Title An Analysis of a Compact Label-Free Guiding-Wave Biosensor Based on a Semiconductor-Clad Dielectric Strip Waveguide
URI https://www.ncbi.nlm.nih.gov/pubmed/32545866
https://www.proquest.com/docview/2414631766/abstract/
https://www.proquest.com/docview/2414409578/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC7349061
https://doaj.org/article/65e45da73c49429196e926bd522019b8
Volume 20
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