Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo

• Published in: PLoS neglected tropical diseases Vol. 7; no. 6; p. e2257
• Main Authors: Gandini, Mariana, Gras, Christophe, Azeredo, Elzinandes Leal, Pinto, Luzia Maria de Oliveira, Smith, Nikaïa, Despres, Philippe, da Cunha, Rivaldo Venâncio, de Souza, Luiz José, Kubelka, Claire Fernandes, Herbeuval, Jean-Philippe
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2013; Public Library of Science (PLoS)
• Subjects: Adult; Biology; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - virology; Dengue virus; Dengue Virus - immunology; Dengue viruses; Female; Flow Cytometry; Humans; Interferon-alpha - blood; Male; Medicine; Middle Aged; Monocytes; Physiological aspects; TNF-Related Apoptosis-Inducing Ligand - metabolism; Young Adult

Dengue displays a broad spectrum of clinical manifestations that may vary from asymptomatic to severe and even fatal features. Plasma leakage/hemorrhages can be caused by a cytokine storm induced by monocytes and dendritic cells during dengue virus (DENV) replication. Plasmacytoid dendritic cells (p...