Pharmacodynamics and pharmacokinetics of single doses of prasugrel 30 mg and clopidogrel 300 mg in healthy chinese and white volunteers: An open-label trial - Small, David S.; Payne, Christopher D.; Kothare, Prajakti; Yuen, Eunice; Natanegara, Fanni; Teng Loh, Mei; Jakubowski, Joseph A.; Richard Lachno, D.; Li, Ying G.; Winters, Kenneth J.; Farid, Nagy A.; Ni, Lan; et al. (Clinical therapeutics, 2010)
Keywords: Administration, Oral; Adult; Asian Continental Ancestry Group; Aspirin; Biological and medical sciences; Blood platelets; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood. Blood coagulation. Reticuloendothelial system; Cardiovascular disease; Cell Adhesion Molecules - blood; China - ethnology; clopidogrel; Coronary vessels; Drug therapy; East Asian population; European Continental Ancestry Group; Female; Flow Cytometry; Humans; Internal Medicine; Laboratories; Male; Medical Education; Medical sciences; Microfilament Proteins - blood; Middle Aged; Pharmacodynamics; Pharmacokinetics; Pharmacology. Drug treatments; Phosphoproteins - blood; Piperazines - administration & dosage; Piperazines - adverse effects; Piperazines - pharmacokinetics; platelet aggregation; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - pharmacokinetics; Platelet Function Tests; prasugrel; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - blood; Receptors, Purinergic P2Y12; Singapore - epidemiology; Thiophenes - administration & dosage; Thiophenes - adverse effects; Thiophenes - pharmacokinetics; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Vein & artery diseases; Young Adult; Asia; China; Singapore; United Kingdom--UK; United States--US; Indianapolis Indiana; clopidogrel; prasugrel; East Asian population; platelet aggregation; Asiatic; Volunteer; Pharmacotherapy; Aggregation; Hemostasis; Race; Antithrombotic agent; Clinical trial; Human; Drug; Pharmacodynamics; Healthy subject; Single dose; Ethnic group; Biological activity; Antiplatelet agent; Prasugrel; Platelet; Treatment; Platelet function; Clopidogrel; Thienopyridine derivative; Caucasoid; Pharmacokinetics