Macropinosomes as units of signal transduction

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 374; no. 1765; p. 20180157
• Main Authors: Swanson, Joel A., Yoshida, Sei
• Format: Journal Article
• Language: English
• Published: England The Royal Society 04.02.2019
• Subjects: Animals; Cell Proliferation - physiology; Endosomes - physiology; Humans; Pinocytosis - physiology; Review; Signal Transduction - physiology; growth factors; actin; phosphatidylinositol 3-kinase

Macropinosome formation occurs as a localized sequence of biochemical activities and associated morphological changes, which may be considered a form of signal transduction leading to the construction of an organelle. Macropinocytosis may also convey information about the availability of extracellul...