Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13

• Published in: Molecular psychiatry Vol. 15; no. 3; pp. 319 - 325
• Main Authors: Francks, C, Tozzi, F, Farmer, A, Vincent, J B, Rujescu, D, St Clair, D, Muglia, P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2010; Nature Publishing Group
• Subjects: Adult; Aged; Alleles; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Case-Control Studies; Chromosome 19; Chromosomes, Human, Pair 19 - genetics; Datasets; Disease; Gene mapping; Gene polymorphism; Genetic aspects; Genetic Linkage - genetics; Genetic Predisposition to Disease - genetics; Genetic susceptibility; Genetic Testing - methods; Genome-Wide Association Study - methods; Genomes; Humans; Linkage (Genetics); Linkage analysis; Medicine; Medicine & Public Health; Mental disorders; Middle Aged; Multidimensional scaling; Neurosciences; original-article; Pharmacotherapy; Polymorphism, Single Nucleotide; Population Surveillance; Psychiatry; Risk factors; Schizophrenia; Schizophrenia - genetics; Single-nucleotide polymorphism; Susceptibility; Systematic review; Italy; United Kingdom; segmental sharing; schizophrenia; case–control; genome scan

Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism ( SNP ) genotype data in case–control samples, which does not assume a common disease, common variant model. The genome is scanned for extended segments that show increased identity-by-descent s...