The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

• Published in: Cell research Vol. 25; no. 1; pp. 80 - 92
• Main Authors: Bao, Xichen, Wu, Haitao, Zhu, Xihua, Guo, Xiangpeng, Hutchins, Andrew P, Luo, Zhiwei, Song, Hong, Chen, Yongqiang, Lai, Keyu, Yin, Menghui, Xu, Lingxiao, Zhou, Liang, Chen, Jiekai, Wang, Dongye, Qin, Baoming, Frampton, Jon, Tse, Hung-Fat, Pei, Duanqing, Wang, Huating, Zhang, Biliang, Esteban, Miguel A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2015; Nature Publishing Group
• Subjects: 631/337/176/1988; 631/337/384/2568; 631/532/2435; Animals; Apoptosis; Biomedical and Life Sciences; Cell Biology; Cell Proliferation; Cellular Reprogramming; CpG; CpG Islands; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methylation; Heterochromatin - genetics; Heterochromatin - metabolism; Histone-Lysine N-Methyltransferase - metabolism; Histones - genetics; Histones - metabolism; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Life Sciences; Methylation; Mice; Original; original-article; p53; Promoter Regions, Genetic; RNA, Long Noncoding - metabolism; Tumor Suppressor Protein p53 - metabolism; 体细胞; 全能性; 基因启动子; 基因诱导; 甲基化; 重编程; DNA methylation; long noncoding RNAs; somatic cell reprogramming; H3K9 methylation; p53; heterochromatin

Recent studies have boosted our understanding of long noncoding RNAs （IncRNAs） in numerous biological processes, but few have examined their roles in somatic cell reprogramming. Through expression profiling and functional screening, we have identified that the large intergenic noncoding RNA p21 （lin...