Subtype-specific regulatory network rewiring in acute myeloid leukemia

• Published in: Nature genetics Vol. 51; no. 1; pp. 151 - 162
• Main Authors: Assi, Salam A., Imperato, Maria Rosaria, Coleman, Daniel J. L., Pickin, Anna, Potluri, Sandeep, Ptasinska, Anetta, Chin, Paulynn Suyin, Blair, Helen, Cauchy, Pierre, James, Sally R., Zacarias-Cabeza, Joaquin, Gilding, L. Niall, Beggs, Andrew, Clokie, Sam, Loke, Justin C., Jenkin, Phil, Uddin, Ash, Delwel, Ruud, Richards, Stephen J., Raghavan, Manoj, Griffiths, Michael J., Heidenreich, Olaf, Cockerill, Peter N., Bonifer, Constanze
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2019; Nature Publishing Group
• Subjects: 13/106; 38/23; 38/39; 38/47; 38/89; 38/90; 38/91; 631/337/176; 64; 64/60; 692/699/67/1990/283/1897; Acute myelocytic leukemia; Acute myeloid leukemia; Adult; Aged; Aged, 80 and over; Agriculture; Animal Genetics and Genomics; Biochemistry; Biomedical and Life Sciences; Biomedicine; Blast cells; Cancer Research; Cell cycle; Cellular signal transduction; Chromatin; Data processing; Deoxyribonucleic acid; DNA; DNA binding proteins; DNA methylation; Epigenetic inheritance; Epigenetics; Explosions; Female; Gene expression; Gene Expression Regulation, Leukemic - genetics; Gene Function; Gene Regulatory Networks - genetics; Genes; Genetic aspects; Genetic engineering; Genomes; Human Genetics; Humans; Information management; Kinases; Leukemia; Leukemia, Myeloid, Acute - genetics; Lymphoma; Male; Middle Aged; Mutation; Myeloid leukemia; Nucleophosmin; Occupancy; Proteins; Regulators; Rewiring; Runx1 protein; Signal Transduction - genetics; Signaling; Stem cells; Subgroups; Transcription (Genetics); Transcription factors; Transcription Factors - genetics; Young Adult

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype–specific transcriptional networks, we performed a comprehensive globa...