Speed Controls in Translating Secretory Proteins in Eukaryotes - an Evolutionary Perspective

• Published in: PLoS computational biology Vol. 10; no. 1; p. e1003294
• Main Authors: Mahlab, Shelly, Linial, Michal
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2014; Public Library of Science (PLoS)
• Subjects: Animals; Caenorhabditis elegans; Cattle; Cell Membrane - metabolism; Cluster Analysis; Codon; Computational Biology - methods; Drosophila melanogaster; Efficiency; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Genetic aspects; Genetic translation; Humans; Hypotheses; Membrane proteins; Peptides; Physiological aspects; Plants; Protein Biosynthesis; Protein Folding; Protein research; Protein Sorting Signals; Protein Structure, Tertiary; Proteins; Proteins - chemistry; Proteome; Ribosomes - chemistry; RNA, Transfer - chemistry; Transfer RNA; Translations; Israel; Protein Structure, Tertiary; Cell Membrane; Protein Biosynthesis; Humans; Computational Biology; Ribosomes; Proteome; Endoplasmic Reticulum; Plants; Protein Folding; Protein Sorting Signals; RNA, Transfer; Proteins; Caenorhabditis elegans; Animals; Codon; Cattle; Drosophila melanogaster; Cluster Analysis

Protein translation is the most expensive operation in dividing cells from bacteria to humans. Therefore, managing the speed and allocation of resources is subject to tight control. From bacteria to humans, clusters of relatively rare tRNA codons at the N'-terminal of mRNAs have been implicated...