Multimodal Phenomap of Stargardt Disease Integrating Structural, Psychophysical, and Electrophysiologic Measures of Retinal Degeneration

• Published in: Ophthalmology science (Online) Vol. 4; no. 1; p. 100327
• Main Authors: Abousy, Mya, Antonio-Aguirre, Bani, Aziz, Kanza, Hu, Ming-Wen, Qian, Jiang, Singh, Mandeep S.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2024; Elsevier
• Subjects: ABCA4; Confocal scanning laser ophthalmoscopy; Inherited retinal disease; Juvenile macular dystrophy; Ophthalmology; Optical coherence tomography; Original; MP; Optical coherence tomography; AF; CST; CI; RPE; Inherited retinal disease; ABCA4; FAF; VA; logMAR; ProgStar; Confocal scanning laser ophthalmoscopy; PCA; FAMD; LA; Juvenile macular dystrophy; STGD; DDAF; ERG; TMV; DA; QDAF; low vision; Progression of Atrophy Secondary to Stargardt Disease; visual rehabilitation; OCT; Fundus autofluorescence; juvenile macular dystrophy; optical coherence tomography; definitely decreased autofluorescence; Stargardt Disease; Microperimetry; questionably decreased autofluorescence; retinal pigment epithelium; Electroretinography; UMAP; vitamin A; uniform manifold approximation and projection; gene therapy; Visual acuity; factor analysis of mixed data; confocal scanning laser ophthalmoscopy; vision loss; principal component analysis

To cluster the diverse phenotypic features of Stargardt disease (STGD) using unsupervised clustering of multimodal retinal structure and function data. Retrospective cross-sectional study. Eyes of subjects with STGD and fundus autofluorescence (FAF), OCT, electroretinography (ERG), and microperimetr...