The roles of long noncoding RNAs in the regulation of OCT4 expression

OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various...

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Published inStem cell research & therapy Vol. 13; no. 1; pp. 1 - 383
Main Authors Zhou, Rui-Ting, Ni, Yi-Ran, Zeng, Fan-Jun
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 30.07.2022
BioMed Central
BMC
Subjects
Bladder cancer
Breast cancer
Cancer stem cell
Cell cycle
Chromosomes
Colorectal cancer
DNA methylation
Embryo cells
Embryonic stem cells
Fibroblasts
Gene expression regulation
Genes
Genetic transcription
LncRNA
Metastasis
Methylation
miRNA
Nobel prizes
Oct-4 protein
OCT4
Ovarian cancer
Pluripotency
Post-transcription
Proteins
Review
Stem cells
Transcription factors
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Abstract OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression.
AbstractList OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression. Keywords: LncRNA, OCT4, Cancer stem cell, Gene expression regulation
OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression.
Abstract OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression.
Abstract OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer stem cells. An increasing number of long noncoding RNAs have been reported to participate in the regulation of OCT4 expression through various mechanisms, including binding with the OCT4 gene promoter to regulate local methylation; promoting chromosomal spatial folding to form an inner ring, thereby aggregating OCT4 cis-acting elements scattered in discontinuous sites of the chromosome; competitively binding microRNAs with OCT4 to upregulate OCT4 expression at the posttranscriptional level; and sharing a promoter with OCT4. Moreover, the transcription of some long noncoding RNAs is regulated by OCT4, and certain long noncoding RNAs form feedback regulatory loops with OCT4. In this review, we summarized the research progress of the long noncoding RNAs involved in the regulation of OCT4 expression.
ArticleNumber 383
Audience Academic
Author Zhou, Rui-Ting
Ni, Yi-Ran
Zeng, Fan-Jun
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CitedBy_id crossref_primary_10_1007_s13205_022_03343_8
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Snippet Abstract OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and...
OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and cancer...
Abstract OCT4 is a major transcription factor that maintains the pluripotency of stem cells, including embryonic stem cells, induced pluripotent stem cells and...
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SubjectTerms Bladder cancer
Breast cancer
Cancer stem cell
Cell cycle
Chromosomes
Colorectal cancer
DNA methylation
Embryo cells
Embryonic stem cells
Fibroblasts
Gene expression regulation
Genes
Genetic transcription
LncRNA
Metastasis
Methylation
miRNA
Nobel prizes
Oct-4 protein
OCT4
Ovarian cancer
Pluripotency
Post-transcription
Proteins
Review
Stem cells
Transcription factors
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Title The roles of long noncoding RNAs in the regulation of OCT4 expression
URI https://www.proquest.com/docview/2704042466/abstract/
https://search.proquest.com/docview/2696863818
https://pubmed.ncbi.nlm.nih.gov/PMC9338536
https://doaj.org/article/49ef3bb6b49344668e5fcbb4c88a3430
Volume 13
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