Resveratrol upregulates miR-455-5p to antagonize cisplatin ototoxicity via modulating the PTEN–PI3K–AKT axis

• Published in: Biochemistry and cell biology Vol. 99; no. 3; pp. 385 - 395
• Main Authors: Liu, Yupeng, Wu, Hui, Zhang, Fan, Yang, Jun, He, Jingchun
• Format: Journal Article
• Language: English
• Published: 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7 NRC Research Press 01.05.2021; Canadian Science Publishing NRC Research Press
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Antitoxins; Apoptosis; Brain stem; Cell injury; Cell proliferation; Chemotherapy; Cisplatin; cisplatin ototoxicity; Cochlea; Coloration; Flavonoids; Gene expression; Hair; Hair cells; Hearing; Hearing loss; Immunofluorescence; Injection; Kinases; MicroRNA; miR-455-5p; Organ of Corti; Ototoxicity; ototoxicité du cisplatine; Oxidative stress; Physiological aspects; PI3K–Akt; Properties; PTEN; PTEN protein; Resveratrol; resvératrol; Signal transduction; Signaling; stress oxydant; China

Resveratrol is a non-flavonoid polyphenol compound that exists in many plants, and is considered an antitoxin. This study explores the effects from the regulation of miR-455-5p by resveratrol on cisplatin-induced ototoxicity via the PTEN–PI3K–AKT signaling pathway. For this, House Ear Institute–Orga...