Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

• Published in: Nature genetics Vol. 52; no. 7; pp. 692 - 700
• Main Authors: Reiter, Johannes G., Hung, Wei-Ting, Lee, I-Hsiu, Nagpal, Shriya, Giunta, Peter, Degner, Sebastian, Liu, Gang, Wassenaar, Emma C. E., Jeck, William R., Taylor, Martin S., Farahani, Alexander A., Marble, Hetal D., Knott, Simon, Kranenburg, Onno, Lennerz, Jochen K., Naxerova, Kamila
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2020; Nature Publishing Group
• Subjects: 45/77; 631/208; 631/67/322; Agriculture; Animal Genetics and Genomics; Biological diversity; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer Research; Cohort Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Disease Progression; Evolution; Gene Function; Genetic diversity; Genetic Heterogeneity; Genetic Variation; Heterogeneity; Human Genetics; Humans; Lesions; Liver; Lymph nodes; Lymphatic Metastasis - genetics; Lymphatic system; Mastectomy; Metastases; Metastasis; Models, Biological; Neoplasm Metastasis - genetics; Neoplasm Seeding; Patients; Phylogenetics; Phylogeny; Trees; Tumors

Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different clinical outcomes: lymph node and distant organ m...