Labial gland-derived mesenchymal stem cells and their exosomes ameliorate murine Sjögren's syndrome by modulating the balance of Treg and Th17 cells

• Published in: Stem cell research & therapy Vol. 12; no. 1; pp. 1 - 478
• Main Authors: Li, Boya, Xing, Yixiao, Gan, Yehua, He, Jing, Hua, Hong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 26.08.2021; BioMed Central; BMC
• Subjects: Antibodies; Autoimmune; Autoimmune diseases; Biological response modifiers; Cell culture; Cell differentiation; Cytokines; Diabetes mellitus; Disease; Enzyme-linked immunosorbent assay; Exosomes; Experiments; Flow cytometry; Health aspects; Helper cells; Immunomodulation; Immunosuppressive agents; Inflammation; Interferon; Interleukin 10; Interleukin 17; Interleukin 6; Interleukins; Labial glands; Laboratory animals; Leukocytes (mononuclear); Lymphocytes; Lymphocytes T; Lymphoma; Mesenchymal stem cells; Microscopy; Mortality; Patients; Peripheral blood mononuclear cells; Regulatory T cells; Saliva; Salivary gland; Serum levels; Sjogren's syndrome; Sjögren's syndrome; Stem cells; T cells; T helper 17 cells; Transforming growth factor-b; United States > US

Background Sjögren's syndrome (SS) is a chronic, systemic autoimmune disorder characterized by sicca syndrome and/or systemic manifestations. The disease severely affects the health and life of patients, and the treatment of SS has always been a clinical challenge and essentially palliative. Me...