A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research

• Published in: Psychoneuroendocrinology Vol. 36; no. 8; pp. 1114 - 1126
• Main Authors: MacDonald, Elayne, Dadds, Mark R., Brennan, John L., Williams, Katrina, Levy, Florence, Cauchi, Avril J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2011; Elsevier
• Subjects: Administration, Intranasal - adverse effects; Behavioral psychophysiology; Biological and medical sciences; Drug awareness; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - etiology; Endocrinology & Metabolism; Female; Fundamental and applied biological sciences. Psychology; Hormones and behavior; Human Experimentation; Humans; Intranasal; Male; Mental Processes - drug effects; Mental Processes - physiology; Oxytocin; Oxytocin - administration & dosage; Oxytocin - adverse effects; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Randomized Controlled Trials as Topic; Safety; Side-effects; Social behaviour; Drug awareness; Safety; Social behaviour; Intranasal; Oxytocin; Side-effects; Human; Toxicity; Subjective experience; Awareness; Review; Psychological effect; Social behavior; Social interaction

Human research investigating the impact of intranasal oxytocin on psychological processes has accelerated over the last two decades. No review of side effects, subjective reactions and safety is available. A systematic review of 38 randomised controlled trials conducted between 1990 and 2010 that in...