Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease

• Published in: International journal of experimental pathology Vol. 86; no. 5; pp. 335 - 345
• Main Authors: Turk, James R., Henderson, Kyle K., Vanvickle, Gregory D., Watkins, Justin, Laughlin, M. Harold
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden, USA Blackwell Publishing Ltd/Inc 01.10.2005; Blackwell Science; Blackwell Science Inc
• Subjects: Acetylcholine - pharmacology; Animals; aorta; Aorta, Abdominal; atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - pathology; Atherosclerosis - physiopathology; Biological and medical sciences; Blood and lymphatic vessels; Bradykinin - pharmacology; Cardiology. Vascular system; carotid; Carotid Artery, Common; Cholesterol, Dietary; coronary; Cyclooxygenase Inhibitors - pharmacology; Dietary Fats; Endothelial Cells - pathology; endothelial dysfunction; Endothelium, Vascular - pathology; Endothelium, Vascular - physiopathology; femoral; Femoral Artery; Foam Cells - pathology; hypercholesterolemia; Hypercholesterolemia - pathology; Hypercholesterolemia - physiopathology; In Vitro Techniques; Indomethacin - pharmacology; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Models, Animal; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide Synthase - antagonists & inhibitors; Original; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; porcine; Swine; Tunica Intima; Vasodilation; Endothelial cell; Femur; Cardiovascular disease; Lipids; Early stage; Hyperlipoproteinemia; Lipoprotein; endothelial dysfunction; Vascular disease; femoral; Blood vessel; Atherosclerosis; Aorta; Dyslipemia; Ungulata; coronary; Coronary artery; porcine; Metabolic diseases; Coronary heart disease; Cholesterol; Endothelium; Pig; Vertebrata; Anatomic pathology; Clinical stage; Mammalia; Hypercholesterolemia; Dysfunction; Animal; Carotid; Models; Circulatory system; Artiodactyla

Summary Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and is projected to become the leading cause of mortality in the world. Atherosclerosis is the most important single factor contributing to this disease burden. In this study, we characterize re...