Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 3; pp. 566 - 575
• Main Authors: Ansari, Celina, Tikhomirov, Grigory A., Hong, Su Hyun, Falconer, Robert A., Loadman, Paul M., Gill, Jason H., Castaneda, Rosalinda, Hazard, Florette K., Tong, Ling, Lenkov, Olga D., Felsher, Dean W., Rao, Jianghong, Daldrup-Link, Heike E.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.02.2014; Wiley Subscription Services, Inc
• Subjects: Animals; Antineoplastic Agents - pharmacology; Apoptosis; Biocompatibility; Breast cancer; Cancer; cancer therapy; Caspases - metabolism; Chemical Phenomena - drug effects; Drug delivery systems; Drugs; Enzymes; Female; Fibroblasts - drug effects; Fibroblasts - enzymology; Fibroblasts - pathology; Humans; iron oxide; Magnetic Resonance Imaging; Matrix Metalloproteinases, Membrane-Associated - metabolism; Mice; MMP-14; MR imaging; Nanoparticles; Nanotechnology; Neoplasms - diagnosis; Neoplasms - therapy; NMR; Nuclear magnetic resonance; theranostic; Therapy; Tumors; cancer therapy; iron oxide; MR imaging; nanoparticles; theranostic; MMP-14

A major drawback with current cancer therapy is the prevalence of unrequired dose‐limiting toxicity to non‐cancerous tissues and organs, which is further compounded by a limited ability to rapidly and easily monitor drug delivery, pharmacodynamics and therapeutic response. In this report, the design...