Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics - Tang, Su-Ni; Fu, Junsheng; Nall, Dara; Rodova, Mariana; Shankar, Sharmila; Srivastava, Rakesh K. (International journal of cancer, 2012)
Keywords: Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Cancer; cancer stem cells; Caspase; Caspase 3 - biosynthesis; Catechin - analogs & derivatives; Catechin - pharmacology; Cell activation; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Drug Synergism; EGCG; Epigallocatechin gallate; epithelial mesenchymal transition; Epithelial-Mesenchymal Transition - drug effects; Flavonoids; Gastroenterology. Liver. Pancreas. Abdomen; Green tea; Hedgehog protein; Hedgehog Proteins - metabolism; Homeodomain Proteins - biosynthesis; Humans; LEF/TCF protein; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical research; Medical sciences; Metastases; Molecular modelling; Myc protein; Nanog Homeobox Protein; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Octamer Transcription Factor-3 - biosynthesis; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Plant Extracts - pharmacology; Pluripotency; pluripotency maintaining factors; Pluripotent Stem Cells; Proto-Oncogene Proteins c-bcl-2 - biosynthesis; Proto-Oncogene Proteins c-myc - biosynthesis; Quercetin; Quercetin - pharmacology; RNAi; Rodents; Signal transduction; Signal Transduction - drug effects; Snail protein; sonic hedgehog pathway; Stem cells; TCF Transcription Factors - antagonists & inhibitors; Tea; Transcription factors; Transcription, Genetic - drug effects; Tumorigenesis; Tumors; X-Linked Inhibitor of Apoptosis Protein - biosynthesis; XIAP protein; Human; RNAi; RNA interference; Stem cell; EGCG; sonic hedgehog pathway; Malignant tumor; pluripotency maintaining factors; Cell transformation; Gene silencing; pancreatic cancer; Cancerology; Hedgehog protein; Pancreas cancer; Digestive diseases; Inhibitor; Epithelial mesenchymal transition; cancer stem cells; Tumor cell; Pluripotency; Cancer; Pancreatic disease