Gene conversion causing human inherited disease: Evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair

• Published in: Human mutation Vol. 30; no. 8; pp. 1189 - 1198
• Main Authors: Chuzhanova, Nadia, Chen, Jian-Min, Bacolla, Albino, Patrinos, George P, Férec, Claude, Wells, Robert D, Cooper, David N
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2009
• Subjects: DNA - genetics; DNA Damage; DNA Repair; Gene Conversion; Genetic Diseases, Inborn - genetics; Humans; non‐B DNA; Recombination, Genetic; recombination‐inducing sequence motifs

A variety of DNA sequence motifs including inverted repeats, minisatellites, and the χ recombination hotspot, have been reported in association with gene conversion in human genes causing inherited disease. However, no methodical statistically based analysis has been performed to formalize these obs...