非酒精性脂肪性肝病患者血清25-羟基维生素D水平与相关因素的临床分析

目的分析血清25-羟基维生素D与非酒精性脂肪性肝病（NAFLD）的相关性,为NAFLD防治提供临床依据。方法选择2014年3月-10月在新疆医科大学第一附属医院就诊的维吾尔族、汉族NAFLD患者各200例为NAFLD组,同期体检的维吾尔族、汉族健康者各200例为对照组;对所有研究对象进行问卷调查、体格检查、腹部超声检查以及血液生化指标检测,采用ELISA检测血清25-羟基维生素D水平;计数资料组间比较采用独立样本t检验,计数资料组间比较采用χ2检验。同时采用Spearman相关分析以及多因素Logistic回归分析25-羟基维生素D与NAFLD的关系。结果维吾尔族、汉族人群NAFLD组25-羟...

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Published in临床肝胆病杂志 Vol. 31; no. 7; pp. 1059 - 1062
Main Author 蔡雯 董正惠 王淑霞 杨晓萍 姚华
Format Journal Article
LanguageChinese
Published 新疆医科大学护理学院,乌鲁木齐,830011%新疆医科大学第一附属医院,乌鲁木齐,830054 2015
Subjects
25-羟维生素D2
汉族
维吾尔族
脂肪肝
脂肪肝
维吾尔族
fatty liver
汉族
UYGUR nationality
25-羟维生素D2
HAN nationality
25-hydroxyvitamin D 2
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.07.015

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Summary:目的分析血清25-羟基维生素D与非酒精性脂肪性肝病（NAFLD）的相关性,为NAFLD防治提供临床依据。方法选择2014年3月-10月在新疆医科大学第一附属医院就诊的维吾尔族、汉族NAFLD患者各200例为NAFLD组,同期体检的维吾尔族、汉族健康者各200例为对照组;对所有研究对象进行问卷调查、体格检查、腹部超声检查以及血液生化指标检测,采用ELISA检测血清25-羟基维生素D水平;计数资料组间比较采用独立样本t检验,计数资料组间比较采用χ2检验。同时采用Spearman相关分析以及多因素Logistic回归分析25-羟基维生素D与NAFLD的关系。结果维吾尔族、汉族人群NAFLD组25-羟基维生素D水平低于对照组（P〈0.05）,且血清25-羟基维生素D与NAFLD具有负相关性（r汉=-0.212,r维=-0.220,P值均〈0.01）;多因素Logistic回归分析结果表明血清25-羟基维生素D水平升高是NAFLD的保护因素（OR汉=0.894,P汉=0.015;OR维=0.897,P维=0.025）。结论维吾尔族、汉族人群中血清25-羟基维生素D水平与NAFLD密切相关。
Bibliography:CAI Wen, DONG Zhenghui, WANG Shuxia, et al. （ School of Nursing, Xinfiang Medical University, Urumqi 830011, China）
Objective To analyze the correlation between serum 25- hydroxyvitamin D level and nonalcoholic fatty liver disease（ NAFLD）,and to provide a clinical basis for the prevention and treatment of NAFLD. Methods From March to October,2014,200 Uyghur patients and 200 Han patients with NAFLD in our hospital were enrolled into NAFLD group,while an equal number of healthy Uyghurs and Hans were used as controls. For all subjects,questionnaire survey,physical examination,abdominal ultrasound examination,and blood biochemical examination were performed,and serum 25- hydroxyvitamin D level was determined using enzyme- linked immunosorbent assay. The relationship between 25- hydroxyvitamin D and NAFLD was analyzed by Spearman correlation analysis and multivariate logistic regression analysis. Results Serum 25- hydroxyvitamin D levels in the NAFLD group were significantly lower than those in the control group fo
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.07.015