Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

• Published in: Microbial cell factories Vol. 15; no. 52; p. 53
• Main Authors: Kildegaard, Kanchana R, Jensen, Niels B, Schneider, Konstantin, Czarnotta, Eik, Özdemir, Emre, Klein, Tobias, Maury, Jérôme, Ebert, Birgitta E, Christensen, Hanne B, Chen, Yun, Kim, Il-Kwon, Herrgård, Markus J, Blank, Lars M, Forster, Jochen, Nielsen, Jens, Borodina, Irina
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.03.2016; BioMed Central
• Subjects: 3-Hydroxypropionic acid; Analysis; Brewer's yeast; chemicals; Chloroflexus - enzymology; Chloroflexus - genetics; Coenzyme A; deletion; escherichia-coli; Fermentation; flux analysis; Gene Expression Regulation, Fungal; genes; growth; increases; Influence; Lactic Acid - analogs & derivatives; Lactic Acid - biosynthesis; Metabolic engineering; Metabolic Engineering - methods; Metabolic Networks and Pathways; mutations; Organisms, Genetically Modified; Oxidation-Reduction; Oxidoreductases - genetics; Oxidoreductases - metabolism; Physiological aspects; Redox metabolism; reveals; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Salmonella enterica - enzymology; Salmonella enterica - genetics; yeast; Germany; Metabolic engineering; Redox metabolism; 3-Hydroxypropionic acid; Saccharomyces cerevisiae

In the future, oil- and gas-derived polymers may be replaced with bio-based polymers, produced from renewable feedstocks using engineered cell factories. Acrylic acid and acrylic esters with an estimated world annual production of approximately 6 million tons by 2017 can be derived from 3-hydroxypro...