Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 29; pp. 11800 - 11805
• Main Authors: Mao, Zhiyong, Tian, Xiao, Van Meter, Michael, Ke, Zhonghe, Gorbunova, Vera, Seluanov, Andrei
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.07.2012; National Acad Sciences
• Subjects: Age; Age Factors; Biological Sciences; Cell cycle; Cell Line; Cell lines; cell senescence; Cells; Cellular senescence; Cellular Senescence - physiology; Chromosomes; Delta cells; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA repair; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique; Gene conversion; genome; Genomic Instability; Genomics; homologous recombination; Homologous Recombination - genetics; Homologous Recombination - physiology; Humans; Lymphocytes; middle-aged adults; NAD ADP-ribosyltransferase; neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - metabolism; Polymerase Chain Reaction; Proteins; Sirtuins - metabolism; Tissues; Transfection

Genomic instability is a hallmark of aging tissues. Genomic instability may arise from the inefficient or aberrant function of DNA double-stranded break (DSB) repair. DSBs are repaired by homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). HR is a precise pathway, whereas NHEJ fr...