Molecular role of Cx37 in advanced atherosclerosis: A micro-array study

• Published in: Atherosclerosis Vol. 206; no. 1; pp. 69 - 76
• Main Authors: Derouette, Jean-Paul, Wong, Cindy, Burnier, Laurent, Morel, Sandrine, Sutter, Esther, Galan, Katia, Brisset, Anne C, Roth, Isabelle, Chadjichristos, Christos E, Kwak, Brenda R
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.09.2009; Elsevier
• Subjects: Animals; Apolipoproteins E - deficiency; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Calcinosis - pathology; Cardiology. Vascular system; Cardiovascular; Cholesterol, Dietary - administration & dosage; Connexin; Connexins - physiology; Gap junction; Gap Junction alpha-4 Protein; Gene Expression Profiling; Human health and pathology; Life Sciences; Matrix degradation; Medical sciences; Mice; Oligonucleotide Array Sequence Analysis; Pharmacology. Drug treatments; Plaque calcification; Tissue inflammation; Matrix degradation; Connexin; Plaque calcification; Tissue inflammation; Gap junction; Atherosclerosis; Vascular disease; Cell junction; Calcification; Cardiovascular disease; Inflammation

Abstract Recently, we showed that connexin37 (Cx37) protects against early atherosclerotic lesion development by regulating monocyte adhesion. The expression of this gap junction protein is altered in mouse and human atherosclerotic lesions; it is increased in macrophages newly recruited to the lesi...