MicroRNA-30-3p Suppresses Inflammatory Factor-Induced Endothelial Cell Injury by Targeting TCF21

• Published in: Mediators of inflammation Vol. 2019; no. 2019; pp. 1 - 14
• Main Authors: Qin, Shu, Liu, Tao, Wu, Shiyong, Zhang, Dongying, Chen, Yu, Zhou, Zhenyu, Cai, Guoqiang
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Analysis; Apoptosis; Apoptosis - genetics; Apoptosis - physiology; Aprotinin; Arteriosclerosis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Bioinformatics; Blotting, Western; Cancer; Cardiovascular disease; Cardiovascular diseases; Cell culture; Cell growth; Cell injury; Cell Proliferation - genetics; Cell Proliferation - physiology; Cell viability; China; Chromosome 5; Coronary vessels; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Enzyme-linked immunosorbent assay; Ethylenediaminetetraacetic acid; Fibroblasts; Flow Cytometry; Genomes; Health aspects; Healthy Volunteers; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Inflammation; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - metabolism; Lactic acid; MAP kinase; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Monocytes; Mortality; NF-κB protein; Pathogenesis; Penicillin; Physiology; Reactive oxygen species; Reactive Oxygen Species - metabolism; Real-Time Polymerase Chain Reaction; Regulation; Signal transduction; Smooth muscle; Studies; Therapeutic applications; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; China; United States > US

Atherosclerosis is one of the leading causes of mortality worldwide. Growing evidence suggested that miRNAs contributed to the progression of atherosclerosis. miR-30-5p was found involved in various diseases. However, the role of miR-30-5p in regulation of atherosclerosis is not known. Here, we aim...