Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes

• Published in: The Journal of clinical investigation Vol. 123; no. 1; pp. 493 - 508
• Main Authors: Augello, Michael A, Burd, Craig J, Birbe, Ruth, McNair, Christopher, Ertel, Adam, Magee, Michael S, Frigo, Daniel E, Wilder-Romans, Kari, Shilkrut, Mark, Han, Sumin, Jernigan, Danielle L, Dean, Jeffry L, Fatatis, Alessandro, McDonnell, Donald P, Visakorpi, Tapio, Feng, Felix Y, Knudsen, Karen E
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.01.2013
• Subjects: Alternative Splicing - genetics; Androgens; Animals; Biomedical research; Cell cycle; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclin-dependent kinases; Gene Expression Regulation, Neoplastic - genetics; Genes; Genetic transcription; Humans; Kinases; Male; Metastasis; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Phase transitions; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Signal Transduction; Snail Family Transcription Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptional Activation - genetics; Transplantation, Heterologous; Tumors; United States

Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor divergent and highly oncogenic functions in human cancer. While cyclin D1b is induced during disease progression in many cancer types, the mechanisms underlying cyclin D1b function remain poorly understood. H...