Pulsatilla decoction suppresses matrix metalloproteinase-7-mediated leukocyte recruitment in dextran sulfate sodium-induced colitis mouse model

• Published in: BMC complementary and alternative medicine Vol. 22; no. 1; p. 211
• Main Authors: Lin, Ming-Kuem, Yang, Ya-Ting, Lin, Li-Jen, Yu, Wei-Hsuan, Chen, Huan-Yuan
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.08.2022; BioMed Central; BMC
• Subjects: Analysis; Colon; complement; Cytokines; Dextran; Dextran sulfate; Dextrans; Drinking water; epithelium; Evaluation; fluorescent antibody technique; Gene expression; Herbal medicine; Histology; Homeopathy; Immune response; Immune system; Immunoassay; immunoassays; Immunofluorescence; Immunohistochemistry; Infiltration; Inflammation; Inflammatory bowel disease; Interleukin 6; Intestinal inflammation; Intestine; intestines; Laboratory animals; Leukocyte migration; Leukocyte recruitment; Leukocytes; Leukocytes (neutrophilic); Macrophages; Materia medica and therapeutics; Matrilysin; Matrix metalloproteinase; Matrix metalloproteinase-7; Matrix metalloproteinases; Medical research; Medical treatment; Medicine, Chinese; Metalloproteinase; mice; Neutrophils; Oriental traditional medicine; Pulsatilla; Pulsatilla decoction; Recruitment; Scientific equipment and supplies industry; Sodium; Sulfates; Therapeutics; Traditional Chinese medicine; Ulcerative colitis; United States

Background Intestinal inflammation is considered to be an important characteristic of ulcerative colitis (UC) and the current medical treatments for UC are usually proposed to suppress abnormal intestinal immune responses. Pulsatilla decoction (PD), a traditional Chinese medicine, is frequently used...