Radiation Therapy in Keloids Treatment： History, Strategy,Effectiveness, and Complication

• Published in: Chinese medical journal Vol. 130; no. 14; pp. 1715 - 1721
• Main Authors: Xu, Jing, Yang, Elan, Yu, Nan-Ze, Long, Xiao
• Format: Journal Article
• Language: English
• Published: China Medknow Publications and Media Pvt. Ltd 20.07.2017; Lippincott Williams & Wilkins Ovid Technologies; Peking Union Medical College, Beijing 100730, China%Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100730, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Analysis; Brachytherapy; Care and treatment; Charged particles; Combination Therapy; Keloids; Radiation Therapy; Hospitals; Humans; Keloid - therapy; Keloids; Mastectomy; Plastic surgery; PubMed; Radiation therapy; Radiotherapy; Radiotherapy - methods; Review; Studies; Treatment Outcome; 分数间隔; 历史; 并发症; 放射治疗; 数据库检索; 治疗方案; 瘢痕疙瘩; Radiation Therapy; Combination Therapy; Keloids
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.4103/0366-6999.209896

Objective：Radiation therapy combined with surgical excision was considered as one of the most effective treatment plans for keloid lesions.However,there was no unanimity found over present literatures regarding the issue on optimized treatment strategy for keloids.We here provide a comprehensive review over this issue and emphasize on the influencing factors.Data Sources：The data analyzed in this review were searched from articles included in PubMed and EMBASE databases.Study Selection：The original articles and critical reviews discussing the application of radiation therapy in keloids treatment were selected for this review.Results：The application of radiation therapy has transitioned from simple superficial X-ray irradiation to brachytherapy.Furthermore,several factors including radiation type,dose,fraction,interval,and complications were reviewed,and the results revealed that these factors were significant toward clinical outcome at various levels.Conclusions：Both past and present evidence support the idea that combination therapy of radiation and surgical therapy is safe and feasible.However,the optimization of treatment strategy was based on different radiation types and should take dose,fractions,interval,and complications into consideration,which will then decrease the rate of recurrence and increase the level of satisfaction.