Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization

• Published in: Environmental health perspectives Vol. 130; no. 11; pp. 117009 - 11
• Main Authors: Valdiviezo, Alan, Brown, Grace E., Michell, Ashlin R., Trinconi, Cristiana M., Bodke, Vedant V., Khetani, Salman R., Luo, Yu-Syuan, Chiu, Weihsueh A., Rusyn, Ivan
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.11.2022; Environmental Health Perspectives
• Subjects: Animal models; Animals; Biocompatibility; Carcinogens; Cell culture; Chemicals; Conjugates; Conjugation; Contamination; Environmental aspects; Enzymes; Estimates; Genotoxicity; Glutathione; Health aspects; Health risk assessment; Health risks; Hepatocytes; Humans; In vitro methods and tests; Induced Pluripotent Stem Cells; Kidneys; Laboratories; Liver; Metabolism; Metabolites; Methods; Mice; Micropatterning; Office buildings; Oxidation; Perchloroethylene; Pharmacokinetics; Physiological aspects; Plating; Pluripotency; Rats; Risk assessment; Solvents; Stem cells; Tetrachloroethylene; Tetrachloroethylene - toxicity; Toxicants; Toxicity; Trichloroethene; Trichloroethylene; Trichloroethylene - toxicity; Uncertainty; United States; United States > US
• ISSN: 0091-6765; 1552-9924; 1552-9924
• DOI: 10.1289/EHP12006

Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism of TCE and PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization of metabolism...