Risk of Tuberculosis Reactivation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Receiving Non-Anti-TNF-Targeted Biologics

• Published in: Mediators of inflammation Vol. 2017; no. 2017; pp. 1 - 15
• Main Authors: Ippolito, Giuseppe, Petrone, Linda, Niccoli, Laura, Nannini, Carlotta, Cantini, Fabrizio, Goletti, Delia
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Animals; Ankylosing spondylitis; Arthritis, Psoriatic - metabolism; Arthritis, Psoriatic - microbiology; Arthritis, Psoriatic - physiopathology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - microbiology; Arthritis, Rheumatoid - physiopathology; Comparative analysis; Cytokines; Diseases; Epidemiology; Humans; Immune system; Infections; Infectious diseases; Pharmaceutical industry; Physiological aspects; Psoriasis; Relapse; Review; Rheumatic diseases; Rheumatoid arthritis; Risk factors; Spondylitis, Ankylosing - metabolism; Spondylitis, Ankylosing - microbiology; Spondylitis, Ankylosing - physiopathology; Surveillance; Tuberculosis; Tuberculosis - metabolism; Tuberculosis - pathology; Tumor Necrosis Factor-alpha - metabolism; Variables

Tuberculosis (TB) still represents an important issue for public health in underdeveloped countries, but the use of antitumor necrosis factor agents (anti-TNF) for the treatment of inflammatory rheumatic disorders has reopened the problem also in countries with low TB incidence, due to the increased...