How long do the systemic and ventilatory responses to toluene diisocyanate persist in dermally sensitized mice?

• Published in: Journal of allergy and clinical immunology Vol. 121; no. 2; pp. 456 - 463.e5
• Main Authors: Vanoirbeek, Jeroen A.J., PhD, De Vooght, Vanessa, MSc, Vanhooren, Hadewijch M., MSc, Nawrot, Tim S., PhD, Nemery, Benoit, MD, PhD, Hoet, Peter H.M., PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.02.2008; Elsevier; Elsevier Limited
• Subjects: Administration, Intranasal; Allergy and Immunology; Animals; Biological and medical sciences; Body Weight; Bronchoalveolar Lavage Fluid - chemistry; Bronchoconstrictor Agents; Chemokine CXCL2 - metabolism; dermal sensitization; Ear, External; Experiments; Fundamental and applied biological sciences. Psychology; Fundamental immunology; IFN-γ; IL-4; Immunization; Immunoglobulin E - blood; Immunoglobulin G - blood; Interferon-gamma - metabolism; Interleukin-4 - metabolism; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphocyte Subsets - pathology; lymphocyte subtypes; Male; Medical sciences; Methacholine Chloride; Mice; Mice, Inbred BALB C; MIP-2; Molecular weight; murine model; Neutrophils - pathology; occupational asthma; Olive oil; Respiration; Respiratory Hypersensitivity - complications; Respiratory Hypersensitivity - immunology; Respiratory Hypersensitivity - pathology; Respiratory Hypersensitivity - physiopathology; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin - immunology; Studies; TDI; Time Factors; Toluene 2,4-Diisocyanate - administration & dosage; Toluene 2,4-Diisocyanate - immunology; occupational asthma; MIP-2; IL-4; Airway hyperreactivity; Enhanced pause; dermal sensitization; Penh; Toluene diisocyanate; murine model; AHR; Concanavalin A; BAL; Macrophage inflammatory protein 2; AUC; Resistance; IFN-γ; OA; R; lymphocyte subtypes; Bronchoalveolar lavage; Area under the curve; TDI; ConA; Animal model; Interleukin 4; Immunology; Bronchus disease; Sensitization; Obstructive pulmonary disease; Lung disease; Immunopathology; Respiratory disease; Cytokine; Rodentia; Asthma; Vertebrata; Mammalia; Mouse; Animal; Skin; Derm; Lymphocyte; Macrophage inflammatory protein; Subtype; Occupational medicine; Gamma interferon

Background Years after removal from exposure, workers with occupational asthma still show respiratory symptoms and airway hyperresponsiveness on re-exposure to the offending agent. Objective We investigated the persistence of the respiratory responsiveness to toluene diisocyanate (TDI) in a mouse mo...