Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

• Published in: Nature (London) Vol. 567; no. 7747; pp. 257 - 261
• Main Authors: Jiang, Ying, Sun, Aihua, Zhao, Yang, Ying, Wantao, Sun, Huichuan, Yang, Xinrong, Xing, Baocai, Sun, Wei, Ren, Liangliang, Hu, Bo, Li, Chaoying, Zhang, Li, Qin, Guangrong, Zhang, Menghuan, Chen, Ning, Zhang, Manli, Huang, Yin, Zhou, Jinan, Zhao, Yan, Liu, Mingwei, Zhu, Xiaodong, Qiu, Yang, Sun, Yanjun, Huang, Cheng, Yan, Meng, Wang, Mingchao, Liu, Wei, Tian, Fang, Xu, Huali, Zhou, Jian, Wu, Zhenyu, Shi, Tieliu, Zhu, Weimin, Qin, Jun, Xie, Lu, Fan, Jia, Qian, Xiaohong, He, Fuchu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2019; Nature Publishing Group
• Subjects: 13/105; 13/51; 13/89; 631/45/475; 64/60; 692/699/67/1504/1610; 82/1; 82/16; 82/58; 82/81; Acids; Animals; Bioinformatics; Cancer; Cancer research; Carcinoma; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - virology; Care and treatment; Cell adhesion & migration; Cell cycle; Cell Growth Processes; Cell Movement; Cholesterol; Criminal investigation; Gene expression; Genomes; Hepatitis; Hepatitis B; Hepatitis B virus; Hepatitis B virus - pathogenicity; Hepatocellular carcinoma; Heterogeneity; Homeostasis; Humanities and Social Sciences; Humans; Infection; Infections; Letter; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - virology; Male; Medical prognosis; Medical schools; Metastasis; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy - trends; multidisciplinary; Mutation; Neoplasm Staging; Phosphorylation; Physiological aspects; Principal components analysis; Prognosis; Proteins; Proteomics; Risk analysis; Risk factors; Science; Science (multidisciplinary); Steroids (Organic compounds); Sterol O-acyltransferase; Sterol O-Acyltransferase - genetics; Surgery; Survival; Target recognition; Therapeutic applications; Tumors; Virus diseases; Viruses; Xenografts; Xenotransplantation; United States > US

Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide. Infection with the hepatitis B virus is one of the leading risk factors for developing hepatocellular carcinoma, particularly in East Asia 1 . Although surgical treatment may be effective in the early stages, the fi...