Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Zonisamide on Other Antiepileptics
The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was...
Saved in:
| Published in | Biological & pharmaceutical bulletin Vol. 16; no. 7; pp. 722 - 725 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Pharmaceutical Society of Japan
1993
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-6158 1347-5215 |
| DOI | 10.1248/bpb.16.722 |
Cover
| Abstract | The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the Vd/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs. |
|---|---|
| AbstractList | The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t 1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the Vd/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs.The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t 1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the Vd/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs. The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the Vd/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs. The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t sub(1/2) and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the V sub(d)/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs. The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t 1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the Vd/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs. |
| Author | MIYAKE, Katsushi TANAKA, Naomi KITAURA, Teruaki KIMURA, Yasuhiro KIMURA, Masahiko FUKUCHI, Hiroshi |
| Author_xml | – sequence: 1 fullname: KIMURA, Masahiko – sequence: 1 fullname: MIYAKE, Katsushi – sequence: 1 fullname: TANAKA, Naomi – sequence: 1 fullname: KITAURA, Teruaki – sequence: 1 fullname: KIMURA, Yasuhiro – sequence: 1 fullname: FUKUCHI, Hiroshi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8401412$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1r3DAQxUVJSDdpLr0XDIUeCt5K1oftY1jSNhBIKe0lFzGWR422tuxK2kP--8rZbQ5LIRfp8H7zNHrvnJz4ySMhbxlds0o0n7q5WzO1rqvqFVkxLupSVkyekBVtWVMqJpvX5DzGLaW0phU_I2eNoEywakX0twcII5jpt_OYnClufMIAJrnJF5Mt7ifvIoyux8L54jukuC6urUWTjtSM36UHDMWVTw5nN-Cc7eIbcmphiHh5uC_Iz8_XPzZfy9u7Lzebq9vSKCpSCU0NFEwrKRdW9EJ0zErVdr1d9mRSdYAUuLS9kcitEo2hnCmDUPWy5RW_IB_2vnOY_uwwJj26aHAYwOO0i7qWrcjBsBdBphqp6JPj-yNwO-2Cz5_QTIiWSVnLhXp3oHbdiL2egxshPOpDwFmne92EKcaAVhuXYEk3BXCDZlQvFepcYX5a5wrzyMejkX-m_4U3e3gbE_zCZxRCTn_ABWVty5_w_ZGnnlWTy9fo-V8L07OR |
| CitedBy_id | crossref_primary_10_1016_S0361_9230_00_00333_6 crossref_primary_10_1046_j_1440_1819_2001_00869_x crossref_primary_10_1111_j_1528_1157_1999_tb00916_x crossref_primary_10_1016_0163_7258_95_00021_6 crossref_primary_10_1007_BF03190386 crossref_primary_10_1248_yakushi_123_35 crossref_primary_10_1016_0006_8993_96_82386_9 crossref_primary_10_1016_0896_6974_95_00049_6 |
| ContentType | Journal Article |
| Copyright | The Pharmaceutical Society of Japan Copyright Japan Science and Technology Agency 1993 |
| Copyright_xml | – notice: The Pharmaceutical Society of Japan – notice: Copyright Japan Science and Technology Agency 1993 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7QR 7TK 7U9 8FD FR3 H94 P64 7X8 |
| DOI | 10.1248/bpb.16.722 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Virology and AIDS Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Technology Research Database AIDS and Cancer Research Abstracts Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Virology and AIDS Abstracts Neurosciences Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1347-5215 |
| EndPage | 725 |
| ExternalDocumentID | 3120249861 8401412 10_1248_bpb_16_722 article_bpb1993_16_7_16_7_722_article_char_en |
| Genre | Journal Article |
| GroupedDBID | --- .55 2WC 53G 5GY 6J9 ACGFO ACIWK ACPRK ADBBV AENEX AFFNX AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BAWUL CS3 DIK DU5 E3Z EBS EJD F5P GX1 HH5 JSF JSH KQ8 OK1 P2P RJT RZJ TKC TR2 VH1 X7M ZXP 1CY 23N AAYXX ABJNI BKOMP CITATION JMI MOJWN XSB ZY4 ABTAH CGR CUY CVF ECM EIF NPM 7QP 7QR 7TK 7U9 8FD FR3 H94 P64 7X8 |
| ID | FETCH-LOGICAL-c604t-a87a0ac95034f4d44b1f569bdf0141156bae0a35fdc5e3f648c0316cea2d59323 |
| ISSN | 0918-6158 |
| IngestDate | Fri Jul 11 12:27:40 EDT 2025 Fri Jul 11 07:51:27 EDT 2025 Mon Jun 30 10:11:28 EDT 2025 Sat Sep 28 08:39:43 EDT 2024 Tue Jul 01 02:29:07 EDT 2025 Thu Apr 24 23:08:26 EDT 2025 Wed Sep 03 06:08:06 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c604t-a87a0ac95034f4d44b1f569bdf0141156bae0a35fdc5e3f648c0316cea2d59323 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/bpb1993/16/7/16_7_722/_article/-char/en |
| PMID | 8401412 |
| PQID | 1449155752 |
| PQPubID | 1966364 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_75943471 proquest_miscellaneous_16856032 proquest_journals_1449155752 pubmed_primary_8401412 crossref_citationtrail_10_1248_bpb_16_722 crossref_primary_10_1248_bpb_16_722 jstage_primary_article_bpb1993_16_7_16_7_722_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1993-00-00 |
| PublicationDateYYYYMMDD | 1993-01-01 |
| PublicationDate_xml | – year: 1993 text: 1993-00-00 |
| PublicationDecade | 1990 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan – name: Tokyo |
| PublicationTitle | Biological & pharmaceutical bulletin |
| PublicationTitleAlternate | Biol Pharm Bull |
| PublicationYear | 1993 |
| Publisher | The Pharmaceutical Society of Japan Japan Science and Technology Agency |
| Publisher_xml | – name: The Pharmaceutical Society of Japan – name: Japan Science and Technology Agency |
| References | 15) I. H. Patel, R.H. Levy and R.E. Cutler, Clin. Pharmacol. Ther., 27, 515 (1980). 18) B.K. Martin, Nature (London), 207, 274 (1965). 11) M. Kimura, N. Tanaka, Y. Kimura, K. Miyake, T. Kitaura, H. Fukuchi and Y. Harada, Chem. Pharm. Bull., 40, 193 (1992). 17) A.H. Anton, J. Pharmacol. Exp. Ther., 134, 291 (1961). 19) G.M. Ihler, Pharmacol. Ther., 20, 151 (1983). 8) M. Kimura, N. Tanaka, Y. Kimura, K. Miyake, T. Kitaura and H. Fukuchi, J. Pharmacobio-Dyn., 15, 631 (1992). 1) J.C. Sackellares, P.D. Donofrio, J.G. Wagner, B. Abou-Khalil, S. Berent and K. Aasved-Hoyt, Epilepsia, 26, 206 (1985). 10) O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. Biol. Chem., 193, 265 (1951). 4) T. Ono, K. Yagi and M. Seino, Seishin Igaku, 30, 471 (1988). 20) H. Konishi, K. Morita, T. Ono and H. Shimakawa, Yakuzaigaku, 50, 323 (1990). 9) T. Omura and R. Sato, J. Biol. Chem., 239, 2370 (1964). 5) C. B. Pugh and W.R. Garnett, Clin. Pharm., 10, 335 (1991). 13) Y. Kohda, K. Nishihara, S. Isozaki, Y. Saitoh, F. Nakagawa and Z. Tamura, J. Pharmacobio-Dyn., 6, 46 (1983). 6) J. K. Penry and M.E. Newmark, Ann. Intern. Med., 90, 207 (1979). 16) I.M. Weiner and G.H. Mudge, Am. J. Med., 36, 743 (1964). 3) K. Yagi, M. Seino, T. Mihara, T. Tottori, Y. Numata, M. Tsuji, Y. Inoue, T. Kudo, Y. Watanabe and H. Muranaka, Seishin Igaku, 29, 111 (1987). 7) L. M. Ojemann, R.A. Shastri, A.J. Wilensky, P.N. Friel, R.H. Levy, J. R. McLean and R.A. Buchanan, Ther. Drug. Monit., 8, 293 (1986). 12) K. Yamaoka, T. Tanigawara, T. Nakagawa and T. Uno, J. Pharmacobio-Dyn., 4, 879 (1981). 14) K. Nishihara, Y. Kohda, Y. Saitoh and Y. Honda, Folia Psychiatr. Jpn., 33, 315 (1979). 2) A.J. Wilensky, P.N. Friel, L.M. Ojemann, C.B. Dodrill, K.B. McCormick and R.H. Levy, Epilepsia, 26, 212 (1985). |
| References_xml | – reference: 15) I. H. Patel, R.H. Levy and R.E. Cutler, Clin. Pharmacol. Ther., 27, 515 (1980). – reference: 16) I.M. Weiner and G.H. Mudge, Am. J. Med., 36, 743 (1964). – reference: 10) O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. Biol. Chem., 193, 265 (1951). – reference: 17) A.H. Anton, J. Pharmacol. Exp. Ther., 134, 291 (1961). – reference: 5) C. B. Pugh and W.R. Garnett, Clin. Pharm., 10, 335 (1991). – reference: 7) L. M. Ojemann, R.A. Shastri, A.J. Wilensky, P.N. Friel, R.H. Levy, J. R. McLean and R.A. Buchanan, Ther. Drug. Monit., 8, 293 (1986). – reference: 13) Y. Kohda, K. Nishihara, S. Isozaki, Y. Saitoh, F. Nakagawa and Z. Tamura, J. Pharmacobio-Dyn., 6, 46 (1983). – reference: 6) J. K. Penry and M.E. Newmark, Ann. Intern. Med., 90, 207 (1979). – reference: 18) B.K. Martin, Nature (London), 207, 274 (1965). – reference: 12) K. Yamaoka, T. Tanigawara, T. Nakagawa and T. Uno, J. Pharmacobio-Dyn., 4, 879 (1981). – reference: 11) M. Kimura, N. Tanaka, Y. Kimura, K. Miyake, T. Kitaura, H. Fukuchi and Y. Harada, Chem. Pharm. Bull., 40, 193 (1992). – reference: 20) H. Konishi, K. Morita, T. Ono and H. Shimakawa, Yakuzaigaku, 50, 323 (1990). – reference: 14) K. Nishihara, Y. Kohda, Y. Saitoh and Y. Honda, Folia Psychiatr. Jpn., 33, 315 (1979). – reference: 9) T. Omura and R. Sato, J. Biol. Chem., 239, 2370 (1964). – reference: 2) A.J. Wilensky, P.N. Friel, L.M. Ojemann, C.B. Dodrill, K.B. McCormick and R.H. Levy, Epilepsia, 26, 212 (1985). – reference: 8) M. Kimura, N. Tanaka, Y. Kimura, K. Miyake, T. Kitaura and H. Fukuchi, J. Pharmacobio-Dyn., 15, 631 (1992). – reference: 1) J.C. Sackellares, P.D. Donofrio, J.G. Wagner, B. Abou-Khalil, S. Berent and K. Aasved-Hoyt, Epilepsia, 26, 206 (1985). – reference: 19) G.M. Ihler, Pharmacol. Ther., 20, 151 (1983). – reference: 4) T. Ono, K. Yagi and M. Seino, Seishin Igaku, 30, 471 (1988). – reference: 3) K. Yagi, M. Seino, T. Mihara, T. Tottori, Y. Numata, M. Tsuji, Y. Inoue, T. Kudo, Y. Watanabe and H. Muranaka, Seishin Igaku, 29, 111 (1987). |
| SSID | ssj0007023 |
| Score | 1.4487745 |
| Snippet | The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated... |
| SourceID | proquest pubmed crossref jstage |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 722 |
| SubjectTerms | Animals Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology antiepileptic drug Blood Proteins - metabolism Carbamazepine - blood Carbamazepine - pharmacokinetics Drug Interactions erythrocyte distribution Erythrocytes - drug effects Erythrocytes - metabolism In Vitro Techniques Isoxazoles - pharmacology Male metabolism pharmacokinetic interaction Phenobarbital - blood Phenobarbital - pharmacokinetics Phenytoin - blood Phenytoin - pharmacokinetics protein binding Protein Binding - drug effects Rats Rats, Wistar Valproic Acid - blood Valproic Acid - pharmacokinetics Zonisamide |
| Title | Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Zonisamide on Other Antiepileptics |
| URI | https://www.jstage.jst.go.jp/article/bpb1993/16/7/16_7_722/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/8401412 https://www.proquest.com/docview/1449155752 https://www.proquest.com/docview/16856032 https://www.proquest.com/docview/75943471 |
| Volume | 16 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Biological and Pharmaceutical Bulletin, 1993/07/15, Vol.16(7), pp.722-725 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgILEXBB0ThQGWQJMQS5eLc0O8TNOmCrbBQyr1LbJjB8rWtNrSh-7Xc46dOukY15coik-sKN8X5xz7-DuEvJGur5RXpk6alsJhPImcxGeJI33Jk1AIT2gxndOzaDhiH8fhuK02qneX1GJQXN-6r-R_UIVrgCvukv0HZG2ncAHOAV84AsJw_CuMvzS60-fgKqLwKmo_XDbFv8EJvJ7hUvV0IrUwCECt098aveL1drwBXcF38KInag5Dxbxe5cGvlnwndpxEusy_rU2Gi66Mt17Tny50CaN2ujXjFT_na8s_rZX1qE8nS24Shj61MxKY_9edVPQSCEaNGLsdX6MOj-LOYBmbHcnNfzc2G6B_GtKBOYCDmIuBFw3sLV3d7LPP-fHo5CTPjsbZXXLPj2NP6_0O20AodnWhP_t8jVAt9L3f9rzmmtz_Dt75V_XrwEM7INkj8rCJHOiBocFjckdVPbJ1UPF6Nl3SXapzefUiSY88OFzV8euR3YYlyz2atZvtrvb0LVa3fLlF8ht0oh060VlJW7pAC0U6vaeGTDda0RzJRNfJ9ISMjo-yw6HT1N9wishltcOTmLu8SEM3YCWTjAmvDKNUyBKzgyHwF1y5PAhLWYQqKCOWFPCLiArFfRlCXBBsk41qVqmnhJZCBUmkpM8L-Gv4JfQrJZdFWnJRsET0ydvVq8-LRpwea6Rc5BikAkw5wJR7UQ4w9clrazs3kiy3Wn0wCFqb5jNFG2SttjMHMLetuNkRxpY-2Vnhnjdf_BWEyQzLKcQh9P7KNgOcuMjGKzVbgE2UQBAR_MYiDlGTMfb6ZNvwyT5hwvDF-s_-2PlzsmkSb3EqcIds1JcL9QKc41q81Lz_AU55wpM |
| linkProvider | ABC ChemistRy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacokinetic+interaction+of+zonisamide+in+rats%3A+Effect+of+zonisamide+on+other+antiepileptics&rft.jtitle=Biological+%26+pharmaceutical+bulletin&rft.au=Kimura%2C+M&rft.au=Tanaka%2C+N&rft.au=Kimura%2C+Y&rft.au=Miyake%2C+K&rft.date=1993&rft.issn=0918-6158&rft.volume=16&rft.issue=7&rft.spage=722&rft.epage=725&rft_id=info:doi/10.1248%2Fbpb.16.722&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0918-6158&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0918-6158&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0918-6158&client=summon |