Astroglial heme oxygenase-1 and the origin of corpora amylacea in aging and degenerating neural tissues

• Published in: Experimental neurology Vol. 254; pp. 78 - 89
• Main Authors: Song, Wei, Zukor, Hillel, Liberman, Adrienne, Kaduri, Sagi, Arvanitakis, Zoe, Bennett, David A., Schipper, Hyman M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.04.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Alzheimer disease; Animals; Animals, Newborn; Astrocyte; Astrocytes - cytology; Astrocytes - enzymology; Astrocytes - pathology; Biological and medical sciences; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Corpora amylacea; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Senescence. Regeneration. Transplantation; Female; Fundamental and applied biological sciences. Psychology; Geriatrics; Glycoproteins - metabolism; Green Fluorescent Proteins - genetics; Heme oxygenase-1; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Hippocampus - enzymology; Hippocampus - pathology; Humans; Inclusion Bodies - enzymology; Inclusion Bodies - pathology; Male; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Transgenic; Mild cognitive impairment; Mitochondria; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurology; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Transgenic mice; Vertebrates: nervous system and sense organs; Corpora amylacea; Mitochondria; Alzheimer disease; Mild cognitive impairment; Heme oxygenase-1; Transgenic mice; Astrocyte; Amyloid body; Nervous system diseases; Senescence; Cognitive disorder; Enzyme; Neuroglia; Rodentia; Cerebral disorder; Oxygenase; Vertebrata; Mammalia; Mouse; Animal; Central nervous system disease; Degenerative disease; mild cognitive impairment; Oxidoreductases; Nervous tissue

Corpora amylacea (CA) are glycoproteinaceous (predominantly glial and extracellular) inclusions that accumulate in normal aging brain and, to a greater extent, in Alzheimer disease (AD). Previous pharmacological evidence suggested that up-regulation of endogenous heme oxygenase-1 (HO-1) in astrocyte...