Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses

• Published in: Viruses Vol. 15; no. 9; p. 1908
• Main Authors: Mohd Jaafar, Fauziah, Belhouchet, Mourad, Monsion, Baptiste, Bell-Sakyi, Lesley, Mertens, Peter P. C., Attoui, Houssam
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.09.2023; MDPI
• Subjects: African horse sickness; African horse sickness virus; Animals; antagonists; Apoptosis; Bluetongue; Bluetongue virus; Bluetongue virus - genetics; Caspase 3; Cloning; Deletion mutant; E3L protein; Enzymes; genome; Genomes; Great Island virus; Health aspects; innate responses; Interferon; Interferon Type I; interferons; Life Sciences; Mammalian cells; Mammals; Microbiology and Parasitology; mutants; NS4; orbivirus; Orbivirus - genetics; pathogenesis; Physiological aspects; Plasmids; Proteins; Reoviruses; St. Croix River virus; Thogotovirus; Vaccinia virus; viral nonstructural proteins; Viral proteins; Virology; virulence; Virulence factors; Virus research; Viruses; France; United States > US; Great Island virus; orbivirus; St. Croix River virus; bluetongue virus; innate responses; NS4

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the interferon response in cells infected with BTV or Afric...