Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

• Published in: Nature reviews. Genetics Vol. 8; no. 2; pp. 104 - 115
• Main Authors: Lanctôt, Christian, Cheutin, Thierry, Cremer, Marion, Cavalli, Giacomo, Cremer, Thomas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2007; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biological Transport - physiology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Nucleus - genetics; Cell Nucleus - physiology; Chromatin; Chromatin - genetics; Chromatin - metabolism; Chromatin - physiology; Chromosomes; Drosophila; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Gene Function; Gene loci; Genetic aspects; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome - genetics; Genomes; Human Genetics; Life Sciences; Microarray Analysis - methods; Models, Genetic; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nuclear Proteins - physiology; Physiological aspects; review-article; Time Factors; Topography; Transcriptional Activation; Gene expression; Genome; Regulation(control)

Key Points Chromatin is mobile in the cell nucleus and undergoes movements that are best described as constrained diffusion. The extent of chromatin mobility is maximal in the early G1 phase of the cell cycle and can change depending on the differentiation status of the cell. Chromatin mobility is l...