Induction and Resuscitation of Viable but Nonculturable Corynebacterium diphtheriae

• Published in: Microorganisms (Basel) Vol. 9; no. 5; p. 927
• Main Authors: Hamabata, Takashi, Senoh, Mitsutoshi, Iwaki, Masaaki, Nishiyama, Ayae, Yamamoto, Akihiko, Shibayama, Keigo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2021; MDPI
• Subjects: animal pathogens; Bacteria; Catalase; Coliforms; Communication; Corynebacterium diphtheriae; Diphtheria; Diphtheria toxin; E coli; Epidemics; Escherichia coli; Genes; Laboratories; Low temperature; Molecular weight; Morphology; Nucleotide sequence; Pathogenicity; Pathogens; Principal components analysis; quantitative polymerase chain reaction; Resuscitation; reverse transcription; RNA; RT-qPCR; Scanning electron microscopy; Software; Toxins; transcriptome analysis; Transcriptomics; VBNC; Vibrio cholerae; United States > US; Japan; VBNC; resuscitation; transcriptome analysis; morphology; Corynebacterium diphtheriae; RT-qPCR

Many pathogenic bacteria, including Escherichia coli and Vibrio cholerae, can become viable but nonculturable (VBNC) following exposure to specific stress conditions. Corynebacterium diphtheriae, a known human pathogen causing diphtheria, has not previously been shown to enter the VBNC state. Here,...